BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ANKHD1 ankyrin repeat and KH domain containing 1
APOD apolipoprotein D
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
CCL19 chemokine (C-C motif) ligand 19
CD164 CD164 molecule, sialomucin
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP2B charged multivesicular body protein 2B
CSRP2 cysteine and glycine-rich protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO11 F-box protein 11
G6PD glucose-6-phosphate dehydrogenase
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GSN gelsolin
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL32 interleukin 32
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
NR4A3 nuclear receptor subfamily 4, group A, member 3
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PAPOLA poly(A) polymerase alpha
PI3 peptidase inhibitor 3, skin-derived
PKP1 plakophilin 1
RGS2 regulator of G-protein signaling 2
RHOH ras homolog family member H
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TIMP3 TIMP metallopeptidase inhibitor 3
TXNIP thioredoxin interacting protein
VAMP3 vesicle-associated membrane protein 3
WDR1 WD repeat domain 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ANXA4 annexin A4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASS1 argininosuccinate synthase 1
ATXN1 ataxin 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
CALD1 caldesmon 1
CAST calpastatin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK14 cyclin-dependent kinase 14
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DPP4 dipeptidyl-peptidase 4
DUSP3 dual specificity phosphatase 3
FNDC3B fibronectin type III domain containing 3B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPX1 glutathione peroxidase 1
HOXC6 homeobox C6
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KLHDC2 kelch domain containing 2
KRCC1 lysine-rich coiled-coil 1
LAMB1 laminin, beta 1
MFAP5 microfibrillar associated protein 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTDH metadherin
MYO6 myosin VI
MYRF myelin regulatory factor
NMT1 N-myristoyltransferase 1
NPAS2 neuronal PAS domain protein 2
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PDS5A PDS5 cohesin associated factor A
PKP4 plakophilin 4
PLA2G16 phospholipase A2, group XVI
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RBM15B RNA binding motif protein 15B
RBM34 RNA binding motif protein 34
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT10 septin 10
SPG11 spastic paraplegia 11 (autosomal recessive)
SRGN serglycin
SSR1 signal sequence receptor, alpha
TBC1D31 TBC1 domain family, member 31
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM5 transmembrane protein 5
TOR1A torsin family 1, member A (torsin A)
TRIP6 thyroid hormone receptor interactor 6
UBE3C ubiquitin protein ligase E3C
VCAN versican