BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K06436323_3-ethyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyrimidine-2,4(1H,3H)-dione_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
BACE2 beta-site APP-cleaving enzyme 2
C1ORF116 chromosome 1 open reading frame 116
CA2 carbonic anhydrase II
CD40 CD40 molecule, TNF receptor superfamily member 5
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CTSB cathepsin B
DEFA5 defensin, alpha 5, Paneth cell-specific
DENND1B DENN/MADD domain containing 1B
DUSP22 dual specificity phosphatase 22
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EXT1 exostosin glycosyltransferase 1
FCGBP Fc fragment of IgG binding protein
FGFR1 fibroblast growth factor receptor 1
FLNB filamin B, beta
FST follistatin
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
HHEX hematopoietically expressed homeobox
HOMER3 homer scaffolding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KDM6A lysine (K)-specific demethylase 6A
KIZ kizuna centrosomal protein
KRT13 keratin 13, type I
LAMP1 lysosomal-associated membrane protein 1
LRMP lymphoid-restricted membrane protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MUC4 mucin 4, cell surface associated
NDRG1 N-myc downstream regulated 1
NMB neuromedin B
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX3 pre-B-cell leukemia homeobox 3
PFKP phosphofructokinase, platelet
PGAP3 post-GPI attachment to proteins 3
PLTP phospholipid transfer protein
POU2AF1 POU class 2 associating factor 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMC1A structural maintenance of chromosomes 1A
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON2 spondin 2, extracellular matrix protein
SPRR3 small proline-rich protein 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUSD4 sushi domain containing 4
TGFA transforming growth factor, alpha
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACAT1 acetyl-CoA acetyltransferase 1
AHR aryl hydrocarbon receptor
AOX1 aldehyde oxidase 1
APOC1 apolipoprotein C-I
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ATF1 activating transcription factor 1
BET1 Bet1 golgi vesicular membrane trafficking protein
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDK4 cyclin-dependent kinase 4
CEP57 centrosomal protein 57kDa
CETN3 centrin, EF-hand protein, 3
CHEK1 checkpoint kinase 1
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRYZ crystallin, zeta (quinone reductase)
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EREG epiregulin
ETNPPL ethanolamine-phosphate phospho-lyase
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
FBLN5 fibulin 5
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLT1B golgi transport 1B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPSM2 G-protein signaling modulator 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HRSP12 heat-responsive protein 12
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KCTD3 potassium channel tetramerization domain containing 3
KDM5D lysine (K)-specific demethylase 5D
KLHDC2 kelch domain containing 2
LUM lumican
LYPLA1 lysophospholipase I
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OXCT1 3-oxoacid CoA transferase 1
OXR1 oxidation resistance 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIEZO2 piezo-type mechanosensitive ion channel component 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKP2 plakophilin 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPF4 pre-mRNA processing factor 4
QDPR quinoid dihydropteridine reductase
RABGGTB Rab geranylgeranyltransferase, beta subunit
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RECQL RecQ helicase-like
RHOBTB3 Rho-related BTB domain containing 3
RNF167 ring finger protein 167
S100A13 S100 calcium binding protein A13
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC16A6 solute carrier family 16, member 6
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC38A1 solute carrier family 38, member 1
SMC3 structural maintenance of chromosomes 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORBS1 sorbin and SH3 domain containing 1
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TMEM2 transmembrane protein 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
ZEB2 zinc finger E-box binding homeobox 2