BRD-K06426971_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K06426971_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C4BPA complement component 4 binding protein, alpha
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD163 CD163 molecule
CD300A CD300a molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP4A charged multivesicular body protein 4A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
ELANE elastase, neutrophil expressed
EXT1 exostosin glycosyltransferase 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
INHBA inhibin, beta A
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
LYPD1 LY6/PLAUR domain containing 1
METRN meteorin, glial cell differentiation regulator
MFAP3L microfibrillar-associated protein 3-like
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MNDA myeloid cell nuclear differentiation antigen
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NOX4 NADPH oxidase 4
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PLCB4 phospholipase C, beta 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
S100A8 S100 calcium binding protein A8
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SDC1 syndecan 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNX11 sorting nexin 11
SRGN serglycin
STEAP3 STEAP family member 3, metalloreductase
SUSD4 sushi domain containing 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM45A transmembrane protein 45A
TST thiosulfate sulfurtransferase (rhodanese)
TYROBP TYRO protein tyrosine kinase binding protein
VSIG4 V-set and immunoglobulin domain containing 4
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADIPOQ adiponectin, C1Q and collagen domain containing
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ARFIP2 ADP-ribosylation factor interacting protein 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BIRC3 baculoviral IAP repeat containing 3
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CANX calnexin
CCL20 chemokine (C-C motif) ligand 20
CCNB1 cyclin B1
CCNC cyclin C
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CNN3 calponin 3, acidic
COL15A1 collagen, type XV, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DST dystonin
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GSAP gamma-secretase activating protein
HLA-DRA major histocompatibility complex, class II, DR alpha
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
LTB lymphotoxin beta (TNF superfamily, member 3)
MKL2 MKL/myocardin-like 2
MMP12 matrix metallopeptidase 12
NAMPT nicotinamide phosphoribosyltransferase
NRIP1 nuclear receptor interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PTBP3 polypyrimidine tract binding protein 3
SCML1 sex comb on midleg-like 1 (Drosophila)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELL selectin L
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCL1A T-cell leukemia/lymphoma 1A
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TKTL1 transketolase-like 1
TNPO1 transportin 1
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)