BRD-K06198550_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K06198550_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP8L A kinase (PRKA) anchor protein 8-like
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BHLHE40 basic helix-loop-helix family, member e40
C8ORF4 chromosome 8 open reading frame 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
DAAM1 dishevelled associated activator of morphogenesis 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELL2 elongation factor, RNA polymerase II, 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPX3 glutathione peroxidase 3
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6R interleukin 6 receptor
INHBA inhibin, beta A
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KIAA0125 KIAA0125
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LTBP3 latent transforming growth factor beta binding protein 3
MAP7 microtubule-associated protein 7
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
PDLIM4 PDZ and LIM domain 4
PHACTR2 phosphatase and actin regulator 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SF1 splicing factor 1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
STK17A serine/threonine kinase 17a
TFF3 trefoil factor 3 (intestinal)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
ANXA2 annexin A2
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BGN biglycan
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD200 CD200 molecule
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLDN18 claudin 18
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CTNND1 catenin (cadherin-associated protein), delta 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DEFB1 defensin, beta 1
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FUBP1 far upstream element (FUSE) binding protein 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
HELLS helicase, lymphoid-specific
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LAMP3 lysosomal-associated membrane protein 3
MAPT microtubule-associated protein tau
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NDNF neuron-derived neurotrophic factor
NPDC1 neural proliferation, differentiation and control, 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1IP1 PDZK1 interacting protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTN pleiotrophin
PTPRK protein tyrosine phosphatase, receptor type, K
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
SERINC5 serine incorporator 5
SIRPA signal-regulatory protein alpha
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC35E2B solute carrier family 35, member E2B
SRGN serglycin
SYBU syntabulin (syntaxin-interacting)
TRIM2 tripartite motif containing 2
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZNF395 zinc finger protein 395