BRD-K05804044_AZ-628_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-K05804044_AZ-628_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ANKRD36B ankyrin repeat domain 36B
ARMCX1 armadillo repeat containing, X-linked 1
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF132 chromosome 14 open reading frame 132
CAPG capping protein (actin filament), gelsolin-like
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CCNG2 cyclin G2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CEP350 centrosomal protein 350kDa
CES1 carboxylesterase 1
CFB complement factor B
CHIC2 cysteine-rich hydrophobic domain 2
CPNE3 copine III
CRELD2 cysteine-rich with EGF-like domains 2
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DBT dihydrolipoamide branched chain transacylase E2
EGFL6 EGF-like-domain, multiple 6
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FZD2 frizzled class receptor 2
GALC galactosylceramidase
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GSDMB gasdermin B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
IDS iduronate 2-sulfatase
IRF9 interferon regulatory factor 9
KLHL24 kelch-like family member 24
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LYZ lysozyme
MAP2K5 mitogen-activated protein kinase kinase 5
MAPT microtubule-associated protein tau
MGST3 microsomal glutathione S-transferase 3
MLPH melanophilin
MVP major vault protein
NAV2 neuron navigator 2
NCAM1 neural cell adhesion molecule 1
NOTCH2NL notch 2 N-terminal like
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEK pleckstrin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PXDN peroxidasin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REG1A regenerating islet-derived 1 alpha
RGS1 regulator of G-protein signaling 1
RNASE4 ribonuclease, RNase A family, 4
RPS5 ribosomal protein S5
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT17 synaptotagmin XVII
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB2 transducer of ERBB2, 2
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TUBA1A tubulin, alpha 1a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG2 BCL2-associated athanogene 2
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CD320 CD320 molecule
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKC1 dyskeratosis congenita 1, dyskerin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
GRWD1 glutamate-rich WD repeat containing 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INPP1 inositol polyphosphate-1-phosphatase
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALL mal, T-cell differentiation protein-like
MCM4 minichromosome maintenance complex component 4
MINA MYC induced nuclear antigen
MRPS12 mitochondrial ribosomal protein S12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NR1H2 nuclear receptor subfamily 1, group H, member 2
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLEC plectin
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PPIF peptidylprolyl isomerase F
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUS7 pseudouridylate synthase 7 (putative)
PYCR1 pyrroline-5-carboxylate reductase 1
RAN RAN, member RAS oncogene family
RCC1 regulator of chromosome condensation 1
RFC3 replication factor C (activator 1) 3, 38kDa
S100A2 S100 calcium binding protein A2
SEH1L SEH1-like (S. cerevisiae)
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SLBP stem-loop binding protein
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SRM spermidine synthase
SRP72 signal recognition particle 72kDa
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCTN1 tectonic family member 1
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)