BRD-K05804044_AZ-628_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K05804044_AZ-628_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABHD4 abhydrolase domain containing 4
AKR1C3 aldo-keto reductase family 1, member C3
AMACR alpha-methylacyl-CoA racemase
ARL3 ADP-ribosylation factor-like 3
ARMCX2 armadillo repeat containing, X-linked 2
CALD1 caldesmon 1
CAPN1 calpain 1, (mu/I) large subunit
CCDC92 coiled-coil domain containing 92
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CLIC5 chloride intracellular channel 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTSD cathepsin D
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
FGA fibrinogen alpha chain
FGFR4 fibroblast growth factor receptor 4
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GRAMD1C GRAM domain containing 1C
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HSPB1 heat shock 27kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
LCN2 lipocalin 2
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
NDRG3 NDRG family member 3
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PHACTR2 phosphatase and actin regulator 2
PNMA1 paraneoplastic Ma antigen 1
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLPI secretory leukocyte peptidase inhibitor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRGN serglycin
TALDO1 transaldolase 1
TCTA T-cell leukemia translocation altered
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
UBE3B ubiquitin protein ligase E3B
VAT1 vesicle amine transport 1
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL4C ADP-ribosylation factor-like 4C
BAG3 BCL2-associated athanogene 3
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDK4 cyclin-dependent kinase 4
CHIC2 cysteine-rich hydrophobic domain 2
COCH cochlin
CRABP1 cellular retinoic acid binding protein 1
CTSH cathepsin H
CXCL3 chemokine (C-X-C motif) ligand 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR2 early growth response 2
EXOSC4 exosome component 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HK2 hexokinase 2
HMGB2 high mobility group box 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
KIF14 kinesin family member 14
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NMB neuromedin B
NMU neuromedin U
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDLIM4 PDZ and LIM domain 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PRSS2 protease, serine, 2 (trypsin 2)
RAB20 RAB20, member RAS oncogene family
RAD51C RAD51 paralog C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SFRP1 secreted frizzled-related protein 1
SHB Src homology 2 domain containing adaptor protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
STX1A syntaxin 1A (brain)
TBX3 T-box 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TWIST1 twist family bHLH transcription factor 1
UPP1 uridine phosphorylase 1
VCAN versican