BRD-K05649647_-666_HEPG2_6.0_h_20.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K05649647_-666_HEPG2_6.0_h_20.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BHLHE41 basic helix-loop-helix family, member e41
CAST calpastatin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEMIP cell migration inducing protein, hyaluronan binding
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOK5 docking protein 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EMX2 empty spiracles homeobox 2
EVI2A ecotropic viral integration site 2A
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IGKV4-1 immunoglobulin kappa variable 4-1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MARS methionyl-tRNA synthetase
MSLN mesothelin
MT1F metallothionein 1F
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NUCB2 nucleobindin 2
PDE4B phosphodiesterase 4B, cAMP-specific
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PTX3 pentraxin 3, long
SEC31A SEC31 homolog A (S. cerevisiae)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
THBS1 thrombospondin 1
TPM2 tropomyosin 2 (beta)
VCAN versican
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CHPT1 choline phosphotransferase 1
COCH cochlin
CPVL carboxypeptidase, vitellogenic-like
CSRP2 cysteine and glycine-rich protein 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPX3 glutathione peroxidase 3
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
KANK2 KN motif and ankyrin repeat domains 2
KRT14 keratin 14, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXRA5 matrix-remodelling associated 5
PLK1 polo-like kinase 1
SEPP1 selenoprotein P, plasma, 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
STK26 serine/threonine protein kinase 26
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3