BRD-K05520923_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

93 genes differentially expressed following the BRD-K05520923_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM28 ADAM metallopeptidase domain 28
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APOD apolipoprotein D
BAD BCL2-associated agonist of cell death
C6ORF48 chromosome 6 open reading frame 48
CCR1 chemokine (C-C motif) receptor 1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CHGB chromogranin B
CLDN10 claudin 10
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CPD carboxypeptidase D
DDIT4 DNA-damage-inducible transcript 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
KYNU kynureninase
MYO10 myosin X
N4BP2L2 NEDD4 binding protein 2-like 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPN3 opsin 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PLAGL1 pleiomorphic adenoma gene-like 1
RAB40B RAB40B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF167 ring finger protein 167
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAR steroidogenic acute regulatory protein
STX1A syntaxin 1A (brain)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
CAST calpastatin
CAV2 caveolin 2
CD9 CD9 molecule
COCH cochlin
CXORF57 chromosome X open reading frame 57
CYR61 cysteine-rich, angiogenic inducer, 61
DLC1 DLC1 Rho GTPase activating protein
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GSPT2 G1 to S phase transition 2
HSPA8 heat shock 70kDa protein 8
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL27RA interleukin 27 receptor, alpha
JAG1 jagged 1
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LTBP1 latent transforming growth factor beta binding protein 1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PF4 platelet factor 4
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX4 SRY (sex determining region Y)-box 4
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TPM1 tropomyosin 1 (alpha)
WBP5 WW domain binding protein 5