BRD-K05331696_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K05331696_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
C1QA complement component 1, q subcomponent, A chain
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CD93 CD93 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
LOX lysyl oxidase
MMP11 matrix metallopeptidase 11
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
NEBL nebulette
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRGN serglycin
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDOB aldolase B, fructose-bisphosphate
ARID5B AT rich interactive domain 5B (MRF1-like)
BLNK B-cell linker
CASP2 caspase 2, apoptosis-related cysteine peptidase
CHL1 cell adhesion molecule L1-like
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DUSP10 dual specificity phosphatase 10
EPHA3 EPH receptor A3
FASTKD5 FAST kinase domains 5
FOXC1 forkhead box C1
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPC4 glypican 4
GRB14 growth factor receptor-bound protein 14
HHEX hematopoietically expressed homeobox
HOXC6 homeobox C6
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
KCTD12 potassium channel tetramerization domain containing 12
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KNG1 kininogen 1
LEPR leptin receptor
MAOA monoamine oxidase A
MARCKSL1 MARCKS-like 1
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
OAT ornithine aminotransferase
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PROM1 prominin 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
SRSF7 serine/arginine-rich splicing factor 7
TGFBR3 transforming growth factor, beta receptor III
TRIM22 tripartite motif containing 22