BRD-K05326558_2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K05326558_2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL4 adhesion G protein-coupled receptor L4
BID BH3 interacting domain death agonist
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CORO1A coronin, actin binding protein, 1A
EDN1 endothelin 1
FN1 fibronectin 1
GAS6 growth arrest-specific 6
GJA1 gap junction protein, alpha 1, 43kDa
HDAC9 histone deacetylase 9
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
LUM lumican
MLPH melanophilin
MYBPC2 myosin binding protein C, fast type
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAM1 neural cell adhesion molecule 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PTPRK protein tyrosine phosphatase, receptor type, K
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNASE6 ribonuclease, RNase A family, k6
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
TGFB3 transforming growth factor, beta 3

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BASP1 brain abundant, membrane attached signal protein 1
BST2 bone marrow stromal cell antigen 2
CHPT1 choline phosphotransferase 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DLD dihydrolipoamide dehydrogenase
DMXL2 Dmx-like 2
ECI2 enoyl-CoA delta isomerase 2
ETFA electron-transfer-flavoprotein, alpha polypeptide
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIAA0101 KIAA0101
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
MAPK6 mitogen-activated protein kinase 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PKM pyruvate kinase, muscle
PRDX1 peroxiredoxin 1
RAB1A RAB1A, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS27L ribosomal protein S27-like
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELT selenoprotein T
SKP1 S-phase kinase-associated protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIRP SRA stem-loop interacting RNA binding protein
STXBP1 syntaxin binding protein 1
SUB1 SUB1 homolog (S. cerevisiae)
TM2D1 TM2 domain containing 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN3 tetraspanin 3
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
XPO7 exportin 7