BRD-K05326558_2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K05326558_2-(1,3-Dimethyl-2,6-dioxo-7-propyl-2,3,6,7-tetrahydro-1H-purin-8-ylsulfanyl)-N-(4,5,6,7-tetrahydro-benzothiazol-2-yl)-acetamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADGRG6 adhesion G protein-coupled receptor G6
ATF3 activating transcription factor 3
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
COCH cochlin
CP ceruloplasmin (ferroxidase)
ECM1 extracellular matrix protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM57A family with sequence similarity 57, member A
GCH1 GTP cyclohydrolase 1
GPR171 G protein-coupled receptor 171
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JCHAIN joining chain of multimeric IgA and IgM
LEF1 lymphoid enhancer-binding factor 1
LPL lipoprotein lipase
LY6E lymphocyte antigen 6 complex, locus E
MEIS1 Meis homeobox 1
NGRN neugrin, neurite outgrowth associated
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFML2A olfactomedin-like 2A
PLAT plasminogen activator, tissue
PRDX4 peroxiredoxin 4
RBPMS RNA binding protein with multiple splicing
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
TBX2 T-box 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AZU1 azurocidin 1
BIK BCL2-interacting killer (apoptosis-inducing)
C14ORF132 chromosome 14 open reading frame 132
CAPNS1 calpain, small subunit 1
CPD carboxypeptidase D
CST6 cystatin E/M
DBP D site of albumin promoter (albumin D-box) binding protein
DEPTOR DEP domain containing MTOR-interacting protein
ELANE elastase, neutrophil expressed
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPI glucose-6-phosphate isomerase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HNMT histamine N-methyltransferase
INSR insulin receptor
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
LASP1 LIM and SH3 protein 1
MAPT microtubule-associated protein tau
MET MET proto-oncogene, receptor tyrosine kinase
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
NQO1 NAD(P)H dehydrogenase, quinone 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRTN3 proteinase 3
PSENEN presenilin enhancer gamma secretase subunit
RPL38 ribosomal protein L38
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TPD52L1 tumor protein D52-like 1