BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ATF3 activating transcription factor 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DEFB1 defensin, beta 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSTN destrin (actin depolymerizing factor)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM60A family with sequence similarity 60, member A
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
IFI27 interferon, alpha-inducible protein 27
IL1R1 interleukin 1 receptor, type I
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KYNU kynureninase
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPCAT1 lysophosphatidylcholine acyltransferase 1
MEIS1 Meis homeobox 1
PDGFRL platelet-derived growth factor receptor-like
PLAU plasminogen activator, urokinase
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC38A2 solute carrier family 38, member 2
TM4SF1 transmembrane 4 L six family member 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4

decreased expression

Symbol Name
APOE apolipoprotein E
ATAD2 ATPase family, AAA domain containing 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CXCL8 chemokine (C-X-C motif) ligand 8
GRB14 growth factor receptor-bound protein 14
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
IFRD2 interferon-related developmental regulator 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PDGFC platelet derived growth factor C
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
RAD51C RAD51 paralog C
SACS sacsin molecular chaperone
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SULF1 sulfatase 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TRPS1 trichorhinophalangeal syndrome I
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAN versican
ZNF586 zinc finger protein 586