BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ADM adrenomedullin
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
BACE2 beta-site APP-cleaving enzyme 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD36 CD36 molecule (thrombospondin receptor)
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CST3 cystatin C
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSL cathepsin L
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
ERLIN2 ER lipid raft associated 2
ETV5 ets variant 5
FAS Fas cell surface death receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FST follistatin
GBE1 glucan (1,4-alpha-), branching enzyme 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HAL histidine ammonia-lyase
HBP1 HMG-box transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA2 heat shock 70kDa protein 2
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
ITGB5 integrin, beta 5
KDM3A lysine (K)-specific demethylase 3A
KRT23 keratin 23, type I
LCN2 lipocalin 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MDFIC MyoD family inhibitor domain containing
MLPH melanophilin
MSMO1 methylsterol monooxygenase 1
MVP major vault protein
MYO1D myosin ID
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIS prostaglandin I2 (prostacyclin) synthase
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD3 SMAD family member 3
SQLE squalene epoxidase
SST somatostatin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIMP1 TIMP metallopeptidase inhibitor 1
TRIM22 tripartite motif containing 22
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VIM vimentin
WIPI1 WD repeat domain, phosphoinositide interacting 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
AK1 adenylate kinase 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CKS1B CDC28 protein kinase regulatory subunit 1B
CMC2 C-x(9)-C motif containing 2
EPCAM epithelial cell adhesion molecule
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HOXC10 homeobox C10
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MKI67 marker of proliferation Ki-67
MNS1 meiosis-specific nuclear structural 1
MYCBP MYC binding protein
PARP2 poly (ADP-ribose) polymerase 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RALB v-ral simian leukemia viral oncogene homolog B
RFC2 replication factor C (activator 1) 2, 40kDa
SPP1 secreted phosphoprotein 1
TMX2 thioredoxin-related transmembrane protein 2
TNIK TRAF2 and NCK interacting kinase
TPX2 TPX2, microtubule-associated