BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
C1ORF106 chromosome 1 open reading frame 106
CCL4 chemokine (C-C motif) ligand 4
CCR7 chemokine (C-C motif) receptor 7
CD9 CD9 molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CREM cAMP responsive element modulator
CSTA cystatin A (stefin A)
CTBP2 C-terminal binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP6 fatty acid binding protein 6, ileal
FAM129A family with sequence similarity 129, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
GATA6 GATA binding protein 6
GMPR guanosine monophosphate reductase
H1F0 H1 histone family, member 0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAMLD1 mastermind-like domain containing 1
MICALL1 MICAL-like 1
MUC16 mucin 16, cell surface associated
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NAMPT nicotinamide phosphoribosyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCP4 Purkinje cell protein 4
PDZRN3 PDZ domain containing ring finger 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PMP22 peripheral myelin protein 22
PRUNE2 prune homolog 2 (Drosophila)
PTGES prostaglandin E synthase
REG1B regenerating islet-derived 1 beta
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SATB1 SATB homeobox 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SNAI2 snail family zinc finger 2
SNX11 sorting nexin 11
TRIB2 tribbles pseudokinase 2
TST thiosulfate sulfurtransferase (rhodanese)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAV1 caveolin 1, caveolae protein, 22kDa
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DAPK1 death-associated protein kinase 1
EIF5A eukaryotic translation initiation factor 5A
GPM6B glycoprotein M6B
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LHFP lipoma HMGIC fusion partner
LY96 lymphocyte antigen 96
MT1E metallothionein 1E
MT1X metallothionein 1X
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPDC1 neural proliferation, differentiation and control, 1
NPY1R neuropeptide Y receptor Y1
PCSK6 proprotein convertase subtilisin/kexin type 6
PLS3 plastin 3
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
VNN1 vanin 1