BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

107 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ASMTL acetylserotonin O-methyltransferase-like
BCR breakpoint cluster region
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRAT carnitine O-acetyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
EFHC1 EF-hand domain (C-terminal) containing 1
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
G0S2 G0/G1 switch 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GJA1 gap junction protein, alpha 1, 43kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MLF1 myeloid leukemia factor 1
MMP12 matrix metallopeptidase 12
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAX8 paired box 8
PDGFRL platelet-derived growth factor receptor-like
PGD phosphogluconate dehydrogenase
PPL periplakin
PRUNE prune exopolyphosphatase
PSPH phosphoserine phosphatase
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SIK1 salt-inducible kinase 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
TFPI2 tissue factor pathway inhibitor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3
XPO7 exportin 7

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A6 collagen, type IV, alpha 6
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMBP dynamin binding protein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP1 fatty acid binding protein 1, liver
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HMGA2 high mobility group AT-hook 2
HSPB8 heat shock 22kDa protein 8
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JCHAIN joining chain of multimeric IgA and IgM
LTF lactotransferrin
MSMB microseminoprotein, beta-
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
PFN2 profilin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL38 ribosomal protein L38
SFRP1 secreted frizzled-related protein 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
TF transferrin
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZBTB38 zinc finger and BTB domain containing 38