BRD-K04887706_AKT-inhibitor-1-2_MCF7_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

129 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACLY ATP citrate lyase
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNG2 cyclin G2
CD163 CD163 molecule
CD24 CD24 molecule
CD8A CD8a molecule
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL4A5 collagen, type IV, alpha 5
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CPB1 carboxypeptidase B1 (tissue)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CYR61 cysteine-rich, angiogenic inducer, 61
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM129A family with sequence similarity 129, member A
FAM3C family with sequence similarity 3, member C
FBN2 fibrillin 2
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLHL24 kelch-like family member 24
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT17 keratin 17, type I
LRMP lymphoid-restricted membrane protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCOLN1 mucolipin 1
MTUS1 microtubule associated tumor suppressor 1
NBPF10 neuroblastoma breakpoint family, member 10
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX1 pre-B-cell leukemia homeobox 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PGM1 phosphoglucomutase 1
PRSS21 protease, serine, 21 (testisin)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SEPP1 selenoprotein P, plasma, 1
SNAP25 synaptosomal-associated protein, 25kDa
SPARCL1 SPARC-like 1 (hevin)
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYT1 synaptotagmin I
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP1 tight junction protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNPO1 transportin 1
TRBC1 T cell receptor beta constant 1
TSPAN1 tetraspanin 1
VCAM1 vascular cell adhesion molecule 1
VIM vimentin
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CCNE2 cyclin E2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
CRABP1 cellular retinoic acid binding protein 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND2D DENN/MADD domain containing 2D
DHRS11 dehydrogenase/reductase (SDR family) member 11
DKK3 dickkopf WNT signaling pathway inhibitor 3
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EPHB2 EPH receptor B2
FAS Fas cell surface death receptor
FOS FBJ murine osteosarcoma viral oncogene homolog
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GSTA1 glutathione S-transferase alpha 1
H2AFX H2A histone family, member X
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT15 keratin 15, type I
LMO2 LIM domain only 2 (rhombotin-like 1)
MME membrane metallo-endopeptidase
MYLK myosin light chain kinase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NOP16 NOP16 nucleolar protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDZK1 PDZ domain containing 1
PRR7 proline rich 7 (synaptic)
RPS11 ribosomal protein S11
SCGB2A1 secretoglobin, family 2A, member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPON1 spondin 1, extracellular matrix protein
TMEM164 transmembrane protein 164
TSC22D2 TSC22 domain family, member 2
ZDHHC6 zinc finger, DHHC-type containing 6