BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
BHLHE41 basic helix-loop-helix family, member e41
BICC1 BicC family RNA binding protein 1
C3ORF14 chromosome 3 open reading frame 14
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST3 cystatin C
CTGF connective tissue growth factor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EDNRA endothelin receptor type A
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FERMT2 fermitin family member 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HBB hemoglobin, beta
HOPX HOP homeobox
HOXD1 homeobox D1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGF1 insulin-like growth factor 1 (somatomedin C)
IL13RA1 interleukin 13 receptor, alpha 1
ITM2A integral membrane protein 2A
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LPIN1 lipin 1
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MAGEH1 melanoma antigen family H1
MDFIC MyoD family inhibitor domain containing
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDE4D phosphodiesterase 4D, cAMP-specific
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PRNP prion protein
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGS5 regulator of G-protein signaling 5
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SSPN sarcospan
SST somatostatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN8 tetraspanin 8
WASF3 WAS protein family, member 3
WWTR1 WW domain containing transcription regulator 1
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ANO1 anoctamin 1, calcium activated chloride channel
BID BH3 interacting domain death agonist
CDKN2A cyclin-dependent kinase inhibitor 2A
COL4A5 collagen, type IV, alpha 5
GOLGA8A golgin A8 family, member A
KRT17 keratin 17, type I
ODC1 ornithine decarboxylase 1
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SORD sorbitol dehydrogenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
WNT5A wingless-type MMTV integration site family, member 5A