BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALB albumin
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA3 annexin A3
ANXA4 annexin A4
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASS1 argininosuccinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
CALR calreticulin
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CPE carboxypeptidase E
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FGG fibrinogen gamma chain
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
HOPX HOP homeobox
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL17RB interleukin 17 receptor B
IL32 interleukin 32
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MVP major vault protein
NAV2 neuron navigator 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PTPRK protein tyrosine phosphatase, receptor type, K
RAB4A RAB4A, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL37A ribosomal protein L37a
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SFTPC surfactant protein C
SPINK1 serine peptidase inhibitor, Kazal type 1
TCAF1 TRPM8 channel-associated factor 1
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPP1 tripeptidyl peptidase I
TST thiosulfate sulfurtransferase (rhodanese)

decreased expression

Symbol Name
AQP9 aquaporin 9
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
FAM171A1 family with sequence similarity 171, member A1
GATA3 GATA binding protein 3
HAT1 histone acetyltransferase 1
HMGB2 high mobility group box 2
KIF20A kinesin family member 20A
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAL mal, T-cell differentiation protein
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POSTN periostin, osteoblast specific factor
PRC1 protein regulator of cytokinesis 1
PRKCB protein kinase C, beta
REG3A regenerating islet-derived 3 alpha
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB2A2 secretoglobin, family 2A, member 2
SMAD1 SMAD family member 1
SVIL supervillin
TGFBR3 transforming growth factor, beta receptor III
TNC tenascin C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)