BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
C7 complement component 7
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFLAR CASP8 and FADD-like apoptosis regulator
CLU clusterin
COLEC11 collectin sub-family member 11
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FGFR2 fibroblast growth factor receptor 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
MAOB monoamine oxidase B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCALD neurocalcin delta
OGN osteoglycin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGIS prostaglandin I2 (prostacyclin) synthase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SOX4 SRY (sex determining region Y)-box 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
STAR steroidogenic acute regulatory protein
STX1A syntaxin 1A (brain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSC22D3 TSC22 domain family, member 3
ZNF185 zinc finger protein 185 (LIM domain)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COCH cochlin
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
GNAS GNAS complex locus
GRB7 growth factor receptor-bound protein 7
HIST1H4C histone cluster 1, H4c
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
JMJD6 jumonji domain containing 6
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
PLCB4 phospholipase C, beta 4
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase