BRD-K04887706_AKT-inhibitor-1-2_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADIRF adipogenesis regulatory factor
ANXA10 annexin A10
BACE2 beta-site APP-cleaving enzyme 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C14ORF1 chromosome 14 open reading frame 1
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN18 claudin 18
COMT catechol-O-methyltransferase
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
EFNB2 ephrin-B2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXD1 forkhead box D1
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GLS glutaminase
GPX3 glutathione peroxidase 3
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BG histone cluster 1, H2bg
HIST3H2A histone cluster 3, H2a
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IRS1 insulin receptor substrate 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK12 kallikrein-related peptidase 12
LDLR low density lipoprotein receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYRM1 LYR motif containing 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MME membrane metallo-endopeptidase
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PHYH phytanoyl-CoA 2-hydroxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RHOQ ras homolog family member Q
S100A12 S100 calcium binding protein A12
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX4 SRY (sex determining region Y)-box 4
SQLE squalene epoxidase
SSBP2 single-stranded DNA binding protein 2
STON1 stonin 1
STXBP1 syntaxin binding protein 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM97 transmembrane protein 97
TNS3 tensin 3
TSC22D3 TSC22 domain family, member 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATAD2 ATPase family, AAA domain containing 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
COL5A1 collagen, type V, alpha 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DEGS1 delta(4)-desaturase, sphingolipid 1
DLX2 distal-less homeobox 2
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ERGIC2 ERGIC and golgi 2
FEN1 flap structure-specific endonuclease 1
GBP1 guanylate binding protein 1, interferon-inducible
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GOLT1B golgi transport 1B
GPI glucose-6-phosphate isomerase
HAT1 histone acetyltransferase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KRT7 keratin 7, type II
LIG1 ligase I, DNA, ATP-dependent
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
PADI2 peptidyl arginine deiminase, type II
PCNA proliferating cell nuclear antigen
RECQL RecQ helicase-like
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLPI secretory leukocyte peptidase inhibitor
SNRPA1 small nuclear ribonucleoprotein polypeptide A'
SRSF2 serine/arginine-rich splicing factor 2
STK10 serine/threonine kinase 10
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
USP1 ubiquitin specific peptidase 1
ZWINT ZW10 interacting kinetochore protein