BRD-K04887706_AKT-inhibitor-1-2_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDOC aldolase C, fructose-bisphosphate
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1RL complement component 1, r subcomponent-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL13 chemokine (C-X-C motif) ligand 13
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
F5 coagulation factor V (proaccelerin, labile factor)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FMO3 flavin containing monooxygenase 3
FMO5 flavin containing monooxygenase 5
FST follistatin
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP1 insulin-like growth factor binding protein 1
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MSMO1 methylsterol monooxygenase 1
MTMR11 myotubularin related protein 11
PALLD palladin, cytoskeletal associated protein
PHYH phytanoyl-CoA 2-hydroxylase
PLAC8 placenta-specific 8
PRKX protein kinase, X-linked
PRSS8 protease, serine, 8
RBP4 retinol binding protein 4, plasma
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC22A18 solute carrier family 22, member 18
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TRAK2 trafficking protein, kinesin binding 2
TRIB3 tribbles pseudokinase 3
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VNN1 vanin 1

decreased expression

Symbol Name
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNB2 cyclin B2
CENPU centromere protein U
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CST6 cystatin E/M
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FEN1 flap structure-specific endonuclease 1
FGFR3 fibroblast growth factor receptor 3
HBB hemoglobin, beta
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
KIF20A kinesin family member 20A
LIMS1 LIM and senescent cell antigen-like domains 1
LYPD1 LY6/PLAUR domain containing 1
MAPK13 mitogen-activated protein kinase 13
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
RAD23B RAD23 homolog B (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STK10 serine/threonine kinase 10
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)