BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
C10ORF10 chromosome 10 open reading frame 10
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CRIP2 cysteine-rich protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DGKD diacylglycerol kinase, delta 130kDa
DYSF dysferlin
EPCAM epithelial cell adhesion molecule
ERBB3 erb-b2 receptor tyrosine kinase 3
EVI2A ecotropic viral integration site 2A
FASN fatty acid synthase
FGG fibrinogen gamma chain
FN1 fibronectin 1
GBP2 guanylate binding protein 2, interferon-inducible
GPR137B G protein-coupled receptor 137B
GRB7 growth factor receptor-bound protein 7
IGF1R insulin-like growth factor 1 receptor
KDM3A lysine (K)-specific demethylase 3A
LHFP lipoma HMGIC fusion partner
MAN1A1 mannosidase, alpha, class 1A, member 1
MMD monocyte to macrophage differentiation-associated
MYO1B myosin IB
NRP1 neuropilin 1
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
PTN pleiotrophin
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SAT1 spermidine/spermine N1-acetyltransferase 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SPARCL1 SPARC-like 1 (hevin)
SPTSSA serine palmitoyltransferase, small subunit A
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYBU syntabulin (syntaxin-interacting)
TFPI2 tissue factor pathway inhibitor 2
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
CDA cytidine deaminase
CLIC3 chloride intracellular channel 3
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSG3 desmoglein 3
DUSP3 dual specificity phosphatase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT1 keratin 1, type II
LAGE3 L antigen family, member 3
LCN2 lipocalin 2
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFA platelet-derived growth factor alpha polypeptide
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRDX2 peroxiredoxin 2
PTX3 pentraxin 3, long
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SPINK5 serine peptidase inhibitor, Kazal type 5