BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

50 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C10ORF10 chromosome 10 open reading frame 10
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DST dystonin
EGR1 early growth response 1
EGR3 early growth response 3
EPS8 epidermal growth factor receptor pathway substrate 8
GEM GTP binding protein overexpressed in skeletal muscle
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NRN1 neuritin 1
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTN pleiotrophin
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SPTSSA serine palmitoyltransferase, small subunit A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UGCG UDP-glucose ceramide glucosyltransferase
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BABAM1 BRISC and BRCA1 A complex member 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CSTA cystatin A (stefin A)
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
KLF5 Kruppel-like factor 5 (intestinal)
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
LYZ lysozyme
MRPL34 mitochondrial ribosomal protein L34
MUC16 mucin 16, cell surface associated
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SFN stratifin
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TLE4 transducin-like enhancer of split 4