BRD-K04887706_AKT-inhibitor-1-2_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
CCNG2 cyclin G2
CD200 CD200 molecule
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK9 dedicator of cytokinesis 9
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GM2A GM2 ganglioside activator
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LXN latexin
MARCKSL1 MARCKS-like 1
MID1 midline 1
MSMO1 methylsterol monooxygenase 1
MTF2 metal response element binding transcription factor 2
MYO5C myosin VC
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PANK3 pantothenate kinase 3
PLAU plasminogen activator, urokinase
PNMAL1 paraneoplastic Ma antigen family-like 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPB surfactant protein B
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASUN asunder spermatogenesis regulator
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CAPRIN2 caprin family member 2
CCNB2 cyclin B2
CD44 CD44 molecule (Indian blood group)
COTL1 coactosin-like F-actin binding protein 1
DNM1L dynamin 1-like
DTNA dystrobrevin, alpha
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERGIC2 ERGIC and golgi 2
GLIPR1 GLI pathogenesis-related 1
GOLT1B golgi transport 1B
GRWD1 glutamate-rich WD repeat containing 1
IFRD2 interferon-related developmental regulator 2
JUN jun proto-oncogene
LOX lysyl oxidase
MED21 mediator complex subunit 21
MT1M metallothionein 1M
PFKP phosphofructokinase, platelet
PITX1 paired-like homeodomain 1
PLTP phospholipid transfer protein
RCAN1 regulator of calcineurin 1
S100A10 S100 calcium binding protein A10
SCRG1 stimulator of chondrogenesis 1
STK17A serine/threonine kinase 17a
TNC tenascin C
UPK1B uroplakin 1B
WWTR1 WW domain containing transcription regulator 1