BRD-K04853698_LDN-193189_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-K04853698_LDN-193189_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL4C ADP-ribosylation factor-like 4C
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTN3A2 butyrophilin, subfamily 3, member A2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD3D CD3d molecule, delta (CD3-TCR complex)
CD99 CD99 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHPT1 choline phosphotransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND5A DENN/MADD domain containing 5A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ERO1L ERO1-like (S. cerevisiae)
FAT1 FAT atypical cadherin 1
FGF13 fibroblast growth factor 13
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
HBEGF heparin-binding EGF-like growth factor
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IL2RG interleukin 2 receptor, gamma
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KIAA0226L KIAA0226-like
KIAA1033 KIAA1033
LBP lipopolysaccharide binding protein
LEF1 lymphoid enhancer-binding factor 1
LRP4 low density lipoprotein receptor-related protein 4
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MICB MHC class I polypeptide-related sequence B
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OSER1 oxidative stress responsive serine-rich 1
PDGFC platelet derived growth factor C
PFDN4 prefoldin subunit 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGES prostaglandin E synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SP110 SP110 nuclear body protein
SP140L SP140 nuclear body protein-like
SPTBN1 spectrin, beta, non-erythrocytic 1
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB2 tribbles pseudokinase 2
TSPAN3 tetraspanin 3
ZEB1 zinc finger E-box binding homeobox 1
ZMAT3 zinc finger, matrin-type 3
ZNF281 zinc finger protein 281
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARMCX2 armadillo repeat containing, X-linked 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASRGL1 asparaginase like 1
CAST calpastatin
CCNA2 cyclin A2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CDC20 cell division cycle 20
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCXR dicarbonyl/L-xylulose reductase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DENND2D DENN/MADD domain containing 2D
ECI1 enoyl-CoA delta isomerase 1
EHD2 EH-domain containing 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FRMD4B FERM domain containing 4B
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRB14 growth factor receptor-bound protein 14
HLF hepatic leukemia factor
HMG20B high mobility group 20B
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LAPTM5 lysosomal protein transmembrane 5
LIG1 ligase I, DNA, ATP-dependent
MATN2 matrilin 2
MGP matrix Gla protein
MSRB2 methionine sulfoxide reductase B2
NET1 neuroepithelial cell transforming 1
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBX1 pre-B-cell leukemia homeobox 1
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PGRMC1 progesterone receptor membrane component 1
PHGDH phosphoglycerate dehydrogenase
PLXNB2 plexin B2
PNKP polynucleotide kinase 3'-phosphatase
PRAF2 PRA1 domain family, member 2
PRKCD protein kinase C, delta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RBKS ribokinase
RPA1 replication protein A1, 70kDa
S100A11 S100 calcium binding protein A11
S100A4 S100 calcium binding protein A4
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SORT1 sortilin 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPON1 spondin 1, extracellular matrix protein
SREBF1 sterol regulatory element binding transcription factor 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TACSTD2 tumor-associated calcium signal transducer 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TECR trans-2,3-enoyl-CoA reductase
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TJP2 tight junction protein 2
TMSB15A thymosin beta 15a
TNS1 tensin 1
TP53 tumor protein p53
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN4 tetraspanin 4
TTC39A tetratricopeptide repeat domain 39A
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2