BRD-K04853698_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-K04853698_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
AKAP13 A kinase (PRKA) anchor protein 13
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BGN biglycan
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EDNRA endothelin receptor type A
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EXPH5 exophilin 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FKBP4 FK506 binding protein 4, 59kDa
FMOD fibromodulin
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
IPO13 importin 13
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUND jun D proto-oncogene
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MZB1 marginal zone B and B1 cell-specific protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NXF1 nuclear RNA export factor 1
P3H2 prolyl 3-hydroxylase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PYCARD PYD and CARD domain containing
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SNAI2 snail family zinc finger 2
SOX17 SRY (sex determining region Y)-box 17
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BST2 bone marrow stromal cell antigen 2
BZW1 basic leucine zipper and W2 domains 1
CALU calumenin
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNG1 cyclin G1
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CD59 CD59 molecule, complement regulatory protein
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CHPT1 choline phosphotransferase 1
CLU clusterin
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CNOT7 CCR4-NOT transcription complex, subunit 7
COX11 COX11 cytochrome c oxidase copper chaperone
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CTSC cathepsin C
CTSH cathepsin H
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4B eukaryotic translation initiation factor 4B
FDXR ferredoxin reductase
FOLR1 folate receptor 1 (adult)
GDE1 glycerophosphodiester phosphodiesterase 1
GLB1 galactosidase, beta 1
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
GTF2H5 general transcription factor IIH, polypeptide 5
HAUS4 HAUS augmin-like complex, subunit 4
HDAC1 histone deacetylase 1
HN1 hematological and neurological expressed 1
HN1L hematological and neurological expressed 1-like
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IGFBP1 insulin-like growth factor binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KIF5B kinesin family member 5B
LAMC1 laminin, gamma 1 (formerly LAMB2)
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MDH1 malate dehydrogenase 1, NAD (soluble)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MXRA7 matrix-remodelling associated 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
PBK PDZ binding kinase
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
PRCP prolylcarboxypeptidase (angiotensinase C)
PRDX1 peroxiredoxin 1
PROS1 protein S (alpha)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RBBP4 retinoblastoma binding protein 4
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPN2 ribophorin II
RPS11 ribosomal protein S11
SEPT9 septin 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFN stratifin
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SORD sorbitol dehydrogenase
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF9 serine/arginine-rich splicing factor 9
SSR1 signal sequence receptor, alpha
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOM stomatin
SYNGR2 synaptogyrin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TMED3 transmembrane emp24 protein transport domain containing 3
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
WBSCR22 Williams Beuren syndrome chromosome region 22
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta