BRD-K04801023_SAR-245408_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K04801023_SAR-245408_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA10 annexin A10
BASP1 brain abundant, membrane attached signal protein 1
C10ORF10 chromosome 10 open reading frame 10
C5AR1 complement component 5a receptor 1
CBR3 carbonyl reductase 3
CFD complement factor D (adipsin)
CHN1 chimerin 1
CLEC3B C-type lectin domain family 3, member B
COL5A1 collagen, type V, alpha 1
COLEC12 collectin sub-family member 12
CTSS cathepsin S
CYTH1 cytohesin 1
DACH1 dachshund family transcription factor 1
DAPK1 death-associated protein kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FHL1 four and a half LIM domains 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FN1 fibronectin 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GPX2 glutathione peroxidase 2
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HNMT histamine N-methyltransferase
IGF1R insulin-like growth factor 1 receptor
KLF4 Kruppel-like factor 4 (gut)
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
MAST2 microtubule associated serine/threonine kinase 2
MCOLN1 mucolipin 1
MTUS1 microtubule associated tumor suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDGFRL platelet-derived growth factor receptor-like
PELI1 pellino E3 ubiquitin protein ligase 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLIT2 slit homolog 2 (Drosophila)
SPINK1 serine peptidase inhibitor, Kazal type 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TLR4 toll-like receptor 4
TOMM34 translocase of outer mitochondrial membrane 34
TREM1 triggering receptor expressed on myeloid cells 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOE apolipoprotein E
BCHE butyrylcholinesterase
CA1 carbonic anhydrase I
CALB1 calbindin 1, 28kDa
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
CLDN1 claudin 1
CLU clusterin
COL15A1 collagen, type XV, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CST7 cystatin F (leukocystatin)
CTSW cathepsin W
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FBXO3 F-box protein 3
FJX1 four jointed box 1 (Drosophila)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
HSPA2 heat shock 70kDa protein 2
IGHM immunoglobulin heavy constant mu
IL32 interleukin 32
ITM2A integral membrane protein 2A
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
LOC100505650 uncharacterized LOC100505650
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
NKG7 natural killer cell granule protein 7
PARP2 poly (ADP-ribose) polymerase 2
PDHX pyruvate dehydrogenase complex, component X
PLAU plasminogen activator, urokinase
PRF1 perforin 1 (pore forming protein)
SAMD4A sterile alpha motif domain containing 4A
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
TARP TCR gamma alternate reading frame protein
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRIB2 tribbles pseudokinase 2
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
XCL1 chemokine (C motif) ligand 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZMYM2 zinc finger, MYM-type 2