BRD-K04546108_JAK3 Inhibitor VI_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C3 aldo-keto reductase family 1, member C3
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CD1E CD1e molecule
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CHI3L2 chitinase 3-like 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM131A family with sequence similarity 131, member A
FHL1 four and a half LIM domains 1
FOXC1 forkhead box C1
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLF10 Kruppel-like factor 10
LAPTM4B lysosomal protein transmembrane 4 beta
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
OAT ornithine aminotransferase
PAM peptidylglycine alpha-amidating monooxygenase
PNP purine nucleoside phosphorylase
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PRKD3 protein kinase D3
PRR7 proline rich 7 (synaptic)
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
S100A10 S100 calcium binding protein A10
S100A8 S100 calcium binding protein A8
SCGB2A1 secretoglobin, family 2A, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPPP3 tubulin polymerization-promoting protein family member 3
TSPAN7 tetraspanin 7
VIM vimentin
XIST X inactive specific transcript (non-protein coding)
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACPP acid phosphatase, prostate
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BRD8 bromodomain containing 8
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF116 chromosome 1 open reading frame 116
C2CD5 C2 calcium-dependent domain containing 5
CCNA2 cyclin A2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CIRBP cold inducible RNA binding protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
F3 coagulation factor III (thromboplastin, tissue factor)
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FXYD3 FXYD domain containing ion transport regulator 3
GSS glutathione synthetase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
JCHAIN joining chain of multimeric IgA and IgM
KDM4B lysine (K)-specific demethylase 4B
KDM5D lysine (K)-specific demethylase 5D
KIF2C kinesin family member 2C
KIF5C kinesin family member 5C
KLK2 kallikrein-related peptidase 2
LAMB1 laminin, beta 1
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
MAGED2 melanoma antigen family D2
MCM5 minichromosome maintenance complex component 5
MRPS30 mitochondrial ribosomal protein S30
MTA1 metastasis associated 1
NBN nibrin
NDC80 NDC80 kinetochore complex component
NEFH neurofilament, heavy polypeptide
NET1 neuroepithelial cell transforming 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPEPL1 aminopeptidase-like 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PIH1D1 PIH1 domain containing 1
PLA1A phospholipase A1 member A
PNISR PNN-interacting serine/arginine-rich protein
PRC1 protein regulator of cytokinesis 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RBPMS RNA binding protein with multiple splicing
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOT1 ras homolog family member T1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SETBP1 SET binding protein 1
SFRP1 secreted frizzled-related protein 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC4 structural maintenance of chromosomes 4
SRSF5 serine/arginine-rich splicing factor 5
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNE2 spectrin repeat containing, nuclear envelope 2
TACC3 transforming, acidic coiled-coil containing protein 3
TARP TCR gamma alternate reading frame protein
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TMEM87A transmembrane protein 87A
TOM1L1 target of myb1 (chicken)-like 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
U2SURP U2 snRNP-associated SURP domain containing
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
USP9Y ubiquitin specific peptidase 9, Y-linked