BRD-K04546108_JAK3 Inhibitor VI_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

177 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR3 atypical chemokine receptor 3
ALAS1 5'-aminolevulinate synthase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BTG3 BTG family, member 3
CALD1 caldesmon 1
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CXADR coxsackie virus and adenovirus receptor
DDIT4 DNA-damage-inducible transcript 4
DUSP8 dual specificity phosphatase 8
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
ERV3-2 endogenous retrovirus group 3, member 2
FGFR1 fibroblast growth factor receptor 1
FHL1 four and a half LIM domains 1
GARS glycyl-tRNA synthetase
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IQGAP1 IQ motif containing GTPase activating protein 1
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT16 keratin 16, type I
MARS methionyl-tRNA synthetase
MCAM melanoma cell adhesion molecule
MFAP5 microfibrillar associated protein 5
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYO6 myosin VI
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDE8B phosphodiesterase 8B
PHGDH phosphoglycerate dehydrogenase
PLTP phospholipid transfer protein
PPARD peroxisome proliferator-activated receptor delta
PROSC proline synthetase co-transcribed homolog (bacterial)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHOQ ras homolog family member Q
RTN3 reticulon 3
S100A4 S100 calcium binding protein A4
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYBU syntabulin (syntaxin-interacting)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
ASF1A anti-silencing function 1A histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C6ORF120 chromosome 6 open reading frame 120
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CD8A CD8a molecule
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CEP70 centrosomal protein 70kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIRBP cold inducible RNA binding protein
COL6A3 collagen, type VI, alpha 3
CST1 cystatin SN
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETV1 ets variant 1
FAM64A family with sequence similarity 64, member A
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KYNU kynureninase
LAMA3 laminin, alpha 3
LYPD1 LY6/PLAUR domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MLPH melanophilin
MPC1 mitochondrial pyruvate carrier 1
MTSS1 metastasis suppressor 1
NEK2 NIMA-related kinase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NKX3-1 NK3 homeobox 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLK1 polo-like kinase 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PSIP1 PC4 and SFRS1 interacting protein 1
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RHOBTB3 Rho-related BTB domain containing 3
RIN2 Ras and Rab interactor 2
SEPT6 septin 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKAP2 src kinase associated phosphoprotein 2
SMC4 structural maintenance of chromosomes 4
SNAI2 snail family zinc finger 2
SOBP sine oculis binding protein homolog (Drosophila)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WDR61 WD repeat domain 61
WTAP Wilms tumor 1 associated protein
ZIC1 Zic family member 1