BRD-K04546108_JAK3 Inhibitor VI_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

279 genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BTG3 BTG family, member 3
C2 complement component 2
C3 complement component 3
CA1 carbonic anhydrase I
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CD163 CD163 molecule
CD93 CD93 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELF2 CUGBP, Elav-like family member 2
CFI complement factor I
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPT dermatopontin
E2F2 E2F transcription factor 2
EFNB2 ephrin-B2
ESRP1 epithelial splicing regulatory protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD3 FXYD domain containing ion transport regulator 3
FXYD6 FXYD domain containing ion transport regulator 6
FZD6 frizzled class receptor 6
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GSTT1 glutathione S-transferase theta 1
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HNMT histamine N-methyltransferase
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
IGLL1 immunoglobulin lambda-like polypeptide 1
IL1A interleukin 1, alpha
IRX5 iroquois homeobox 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAOA monoamine oxidase A
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NSG1 neuron specific gene family member 1
NUCB1 nucleobindin 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
ORM1 orosomucoid 1
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZD2 PDZ domain containing 2
PER2 period circadian clock 2
PIR pirin (iron-binding nuclear protein)
PLAGL1 pleiomorphic adenoma gene-like 1
PLD3 phospholipase D family, member 3
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TAPBP TAP binding protein (tapasin)
TICAM1 toll-like receptor adaptor molecule 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX thymocyte selection-associated high mobility group box
TPGS2 tubulin polyglutamylase complex subunit 2
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB10 zinc finger and BTB domain containing 10
ZNF211 zinc finger protein 211
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AURKA aurora kinase A
AURKB aurora kinase B
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BRCA1 breast cancer 1, early onset
BZW2 basic leucine zipper and W2 domains 2
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CEP68 centrosomal protein 68kDa
CHRDL1 chordin-like 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CNOT7 CCR4-NOT transcription complex, subunit 7
COTL1 coactosin-like F-actin binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1A1 casein kinase 1, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSP desmoplakin
EAPP E2F-associated phosphoprotein
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM111A family with sequence similarity 111, member A
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GOLGA8A golgin A8 family, member A
HJURP Holliday junction recognition protein
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
ITGA6 integrin, alpha 6
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA1033 KIAA1033
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KRT18 keratin 18, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MAT2A methionine adenosyltransferase II, alpha
MEGF9 multiple EGF-like-domains 9
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MYO1E myosin IE
NAV2 neuron navigator 2
NDE1 nudE neurodevelopment protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NOSIP nitric oxide synthase interacting protein
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP37 nucleoporin 37kDa
OSBPL3 oxysterol binding protein-like 3
OSBPL8 oxysterol binding protein-like 8
OXTR oxytocin receptor
PAX8 paired box 8
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PFKP phosphofructokinase, platelet
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKP4 plakophilin 4
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLS3 plastin 3
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
PSRC1 proline/serine-rich coiled-coil 1
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100A7 S100 calcium binding protein A7
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SEPT6 septin 6
SETX senataxin
SFRP1 secreted frizzled-related protein 1
SH3BP4 SH3-domain binding protein 4
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SYNJ2 synaptojanin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TMEM97 transmembrane protein 97
TNC tenascin C
TRAM2 translocation associated membrane protein 2
TUBA4A tubulin, alpha 4a
TUBB6 tubulin, beta 6 class V
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF185 zinc finger protein 185 (LIM domain)
ZNF638 zinc finger protein 638
ZWILCH zwilch kinetochore protein