BRD-K03829970_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K03829970_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AEBP1 AE binding protein 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
C3ORF14 chromosome 3 open reading frame 14
C7 complement component 7
CAB39 calcium binding protein 39
CADM1 cell adhesion molecule 1
CCR2 chemokine (C-C motif) receptor 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFH complement factor H
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
DEFB1 defensin, beta 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
ECM1 extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
FILIP1L filamin A interacting protein 1-like
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GMPR guanosine monophosphate reductase
GOLM1 golgi membrane protein 1
HECA headcase homolog (Drosophila)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IFI6 interferon, alpha-inducible protein 6
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IGSF3 immunoglobulin superfamily, member 3
KDM5B lysine (K)-specific demethylase 5B
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LRRC17 leucine rich repeat containing 17
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEF2C myocyte enhancer factor 2C
MT1E metallothionein 1E
MXI1 MAX interactor 1, dimerization protein
NLRP2 NLR family, pyrin domain containing 2
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PDE4A phosphodiesterase 4A, cAMP-specific
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RIMS3 regulating synaptic membrane exocytosis 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RSAD2 radical S-adenosyl methionine domain containing 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCF4 transcription factor 4
THBD thrombomodulin
TKTL1 transketolase-like 1
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
UBL5 ubiquitin-like 5
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AMD1 adenosylmethionine decarboxylase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP6 charged multivesicular body protein 6
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCK deoxycytidine kinase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
ECD ecdysoneless homolog (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
GABPB1 GA binding protein transcription factor, beta subunit 1
GPER1 G protein-coupled estrogen receptor 1
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
MALT1 MALT1 paracaspase
MSL1 male-specific lethal 1 homolog (Drosophila)
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1E myosin IE
NBN nibrin
ODAM odontogenic, ameloblast asssociated
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP2 poly (ADP-ribose) polymerase 2
PMP2 peripheral myelin protein 2
PPAP2B phosphatidic acid phosphatase type 2B
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMAD1 SMAD family member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTBN1 spectrin, beta, non-erythrocytic 1
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK17B serine/threonine kinase 17b
TAC1 tachykinin, precursor 1
TCERG1 transcription elongation regulator 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMEM185B transmembrane protein 185B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
USP9Y ubiquitin specific peptidase 9, Y-linked
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1