BRD-K03449891_foretinib_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K03449891_foretinib_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
AQP1 aquaporin 1 (Colton blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CFB complement factor B
CLIC5 chloride intracellular channel 5
COLEC12 collectin sub-family member 12
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DSG2 desmoglein 2
EZR ezrin
F11R F11 receptor
FAM117A family with sequence similarity 117, member A
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LPIN1 lipin 1
MSMO1 methylsterol monooxygenase 1
NPIPB3 nuclear pore complex interacting protein family, member B3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
QPRT quinolinate phosphoribosyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SGCE sarcoglycan, epsilon
SLC22A18 solute carrier family 22, member 18
SQLE squalene epoxidase
SST somatostatin
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GRIA2 glutamate receptor, ionotropic, AMPA 2
NAV3 neuron navigator 3
NUP85 nucleoporin 85kDa
RBP1 retinol binding protein 1, cellular
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
TESC tescalcin
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein