BRD-K03449891_foretinib_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K03449891_foretinib_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C3 aldo-keto reductase family 1, member C3
C1ORF115 chromosome 1 open reading frame 115
C7 complement component 7
CFB complement factor B
COCH cochlin
COLEC12 collectin sub-family member 12
CREG1 cellular repressor of E1A-stimulated genes 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSA cathepsin A
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DPP4 dipeptidyl-peptidase 4
ELANE elastase, neutrophil expressed
F5 coagulation factor V (proaccelerin, labile factor)
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGF13 fibroblast growth factor 13
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
FSCN1 fascin actin-bundling protein 1
GPX4 glutathione peroxidase 4
GRN granulin
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
INSIG1 insulin induced gene 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLHL24 kelch-like family member 24
LAMB2 laminin, beta 2 (laminin S)
LDLR low density lipoprotein receptor
LY6E lymphocyte antigen 6 complex, locus E
MPO myeloperoxidase
NEU1 sialidase 1 (lysosomal sialidase)
NFIB nuclear factor I/B
NQO2 NAD(P)H dehydrogenase, quinone 2
OLFM4 olfactomedin 4
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLS1 plastin 1
PMP22 peripheral myelin protein 22
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SFXN3 sideroflexin 3
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
STAB1 stabilin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TNC tenascin C
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VCAN versican
WWOX WW domain containing oxidoreductase
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AURKB aurora kinase B
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
DICER1 dicer 1, ribonuclease type III
EGFR epidermal growth factor receptor
ESR1 estrogen receptor 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPM6B glycoprotein M6B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MYCBP MYC binding protein
NGRN neugrin, neurite outgrowth associated
NRIP1 nuclear receptor interacting protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORD sorbitol dehydrogenase
TCL1A T-cell leukemia/lymphoma 1A
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
WARS tryptophanyl-tRNA synthetase
ZWINT ZW10 interacting kinetochore protein