BRD-K03449891_foretinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K03449891_foretinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA10 annexin A10
ARMCX1 armadillo repeat containing, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
C4BPA complement component 4 binding protein, alpha
CBR3 carbonyl reductase 3
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTSK cathepsin K
CXORF57 chromosome X open reading frame 57
DUSP6 dual specificity phosphatase 6
EMP2 epithelial membrane protein 2
FABP4 fatty acid binding protein 4, adipocyte
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FST follistatin
GPNMB glycoprotein (transmembrane) nmb
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
HMOX1 heme oxygenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS1 insulin receptor substrate 1
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MATN2 matrilin 2
MEIS2 Meis homeobox 2
METTL7A methyltransferase like 7A
MID1 midline 1
MPDZ multiple PDZ domain protein
NAV2 neuron navigator 2
NKG7 natural killer cell granule protein 7
NUPR1 nuclear protein, transcriptional regulator, 1
PIR pirin (iron-binding nuclear protein)
PPARG peroxisome proliferator-activated receptor gamma
PRKCQ protein kinase C, theta
PTK2B protein tyrosine kinase 2 beta
PTPRK protein tyrosine phosphatase, receptor type, K
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC38A1 solute carrier family 38, member 1
SNN stannin
SNX11 sorting nexin 11
SQSTM1 sequestosome 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
USP6NL USP6 N-terminal like

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CLIC4 chloride intracellular channel 4
COL9A3 collagen, type IX, alpha 3
CPD carboxypeptidase D
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
FAM60A family with sequence similarity 60, member A
FAS Fas cell surface death receptor
GLIPR1 GLI pathogenesis-related 1
GOLM1 golgi membrane protein 1
GOLT1B golgi transport 1B
IER3 immediate early response 3
KRT10 keratin 10, type I
KRT14 keratin 14, type I
LCN2 lipocalin 2
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PDZK1IP1 PDZK1 interacting protein 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRPF4 pre-mRNA processing factor 4
SEPT11 septin 11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMED9 transmembrane emp24 protein transport domain containing 9
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGDH UDP-glucose 6-dehydrogenase
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon