BRD-K03449891_foretinib_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K03449891_foretinib_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APLP2 amyloid beta (A4) precursor-like protein 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD163 CD163 molecule
CDC25B cell division cycle 25B
CFD complement factor D (adipsin)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMD dystrophin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FUCA1 fucosidase, alpha-L- 1, tissue
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEF2C myocyte enhancer factor 2C
MKRN1 makorin ring finger protein 1
PNMA1 paraneoplastic Ma antigen 1
QPRT quinolinate phosphoribosyltransferase
S100A4 S100 calcium binding protein A4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TSC22D3 TSC22 domain family, member 3
VCAN versican
WIPF2 WAS/WASL interacting protein family, member 2
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BTG3 BTG family, member 3
CYB5A cytochrome b5 type A (microsomal)
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM134B family with sequence similarity 134, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
IER3 immediate early response 3
JUN jun proto-oncogene
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
NVL nuclear VCP-like
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TXNRD1 thioredoxin reductase 1