BRD-K03449891_foretinib_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K03449891_foretinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
AGTR1 angiotensin II receptor, type 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF1 chromosome 14 open reading frame 1
C1ORF54 chromosome 1 open reading frame 54
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAT catalase
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CTSD cathepsin D
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DFNA5 deafness, autosomal dominant 5
DHCR7 7-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLRT2 fibronectin leucine rich transmembrane protein 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GJA1 gap junction protein, alpha 1, 43kDa
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSTA1 glutathione S-transferase alpha 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR2 lysophosphatidic acid receptor 2
LRRC16A leucine rich repeat containing 16A
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
METTL7A methyltransferase like 7A
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMRK1 nicotinamide riboside kinase 1
NPEPL1 aminopeptidase-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEG3 paternally expressed 3
PGLS 6-phosphogluconolactonase
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PROM1 prominin 1
PROS1 protein S (alpha)
PYCARD PYD and CARD domain containing
RAB40B RAB40B, member RAS oncogene family
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIRT3 sirtuin 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A6 solute carrier family 16, member 6
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
SRSF5 serine/arginine-rich splicing factor 5
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TMC5 transmembrane channel-like 5
TMEM135 transmembrane protein 135
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1
VNN1 vanin 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELANE elastase, neutrophil expressed
EREG epiregulin
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GINS1 GINS complex subunit 1 (Psf1 homolog)
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HJURP Holliday junction recognition protein
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KRT13 keratin 13, type I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAMLD1 mastermind-like domain containing 1
MARS methionyl-tRNA synthetase
MCM10 minichromosome maintenance complex component 10
MKI67 marker of proliferation Ki-67
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NOP56 NOP56 ribonucleoprotein
ODC1 ornithine decarboxylase 1
ORC6 origin recognition complex, subunit 6
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRDX4 peroxiredoxin 4
PRPF4 pre-mRNA processing factor 4
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SIVA1 SIVA1, apoptosis-inducing factor
SKA1 spindle and kinetochore associated complex subunit 1
SMC4 structural maintenance of chromosomes 4
SPC25 SPC25, NDC80 kinetochore complex component
STC2 stanniocalcin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
UBE2C ubiquitin-conjugating enzyme E2C
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)