BRD-K03406345_azacitidine_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K03406345_azacitidine_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIRC2 baculoviral IAP repeat containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C9ORF3 chromosome 9 open reading frame 3
CADM1 cell adhesion molecule 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
COCH cochlin
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRY1 cryptochrome circadian clock 1
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND5A DENN/MADD domain containing 5A
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGFR epidermal growth factor receptor
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FKBP11 FK506 binding protein 11, 19 kDa
FLNB filamin B, beta
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA13 heat shock protein 70kDa family, member 13
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IL6 interleukin 6
INHBA inhibin, beta A
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KLF2 Kruppel-like factor 2
KLF5 Kruppel-like factor 5 (intestinal)
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARS methionyl-tRNA synthetase
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC13 mucin 13, cell surface associated
NOL7 nucleolar protein 7, 27kDa
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OXSR1 oxidative stress responsive 1
PBX3 pre-B-cell leukemia homeobox 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHGDH phosphoglycerate dehydrogenase
PLEKHA5 pleckstrin homology domain containing, family A member 5
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RTN1 reticulon 1
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SCG2 secretogranin II
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX11 sorting nexin 11
SORBS2 sorbin and SH3 domain containing 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRPR signal recognition particle receptor (docking protein)
SSBP2 single-stranded DNA binding protein 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
SUCO SUN domain containing ossification factor
SYNE2 spectrin repeat containing, nuclear envelope 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNPO1 transportin 1
TUBB2B tubulin, beta 2B class IIb
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
ALDOA aldolase A, fructose-bisphosphate
APMAP adipocyte plasma membrane associated protein
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASRGL1 asparaginase like 1
ATXN1 ataxin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT1
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BIN1 bridging integrator 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CETN2 centrin, EF-hand protein, 2
CKS2 CDC28 protein kinase regulatory subunit 2
COL6A1 collagen, type VI, alpha 1
CRYZ crystallin, zeta (quinone reductase)
CX3CL1 chemokine (C-X3-C motif) ligand 1
DEFB1 defensin, beta 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DMD dystrophin
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ETV1 ets variant 1
FAM3C family with sequence similarity 3, member C
FGFR3 fibroblast growth factor receptor 3
HIST1H4C histone cluster 1, H4c
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT19 keratin 19, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100505650 uncharacterized LOC100505650
LOXL1 lysyl oxidase-like 1
LPIN1 lipin 1
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
MYBPC1 myosin binding protein C, slow type
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PON2 paraoxonase 2
QPRT quinolinate phosphoribosyltransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP5 receptor accessory protein 5
RHOBTB3 Rho-related BTB domain containing 3
S100A12 S100 calcium binding protein A12
S100A4 S100 calcium binding protein A4
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A
ZCCHC24 zinc finger, CCHC domain containing 24