BRD-K03406345_azacitidine_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K03406345_azacitidine_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ADORA2B adenosine A2b receptor
AKAP12 A kinase (PRKA) anchor protein 12
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF5 activating transcription factor 5
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BGN biglycan
C10ORF10 chromosome 10 open reading frame 10
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
CTH cystathionine gamma-lyase
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBN1 drebrin 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FGFR1 fibroblast growth factor receptor 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GLG1 golgi glycoprotein 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
ICAM1 intercellular adhesion molecule 1
INPP1 inositol polyphosphate-1-phosphatase
KIAA0100 KIAA0100
KYNU kynureninase
LAMB1 laminin, beta 1
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MGP matrix Gla protein
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RBM47 RNA binding motif protein 47
RIOK3 RIO kinase 3
RRAGD Ras-related GTP binding D
S100A11 S100 calcium binding protein A11
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX4 SRY (sex determining region Y)-box 4
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TOMM34 translocase of outer mitochondrial membrane 34
TXNRD1 thioredoxin reductase 1
USP22 ubiquitin specific peptidase 22
WARS tryptophanyl-tRNA synthetase
YBX3 Y box binding protein 3
ZBTB16 zinc finger and BTB domain containing 16
ZNF160 zinc finger protein 160

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASRGL1 asparaginase like 1
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CSRP2 cysteine and glycine-rich protein 2
CTSZ cathepsin Z
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPSM2 G-protein signaling modulator 2
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KAZN kazrin, periplakin interacting protein
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MPC2 mitochondrial pyruvate carrier 2
MSMO1 methylsterol monooxygenase 1
MSRB2 methionine sulfoxide reductase B2
NR1H2 nuclear receptor subfamily 1, group H, member 2
OSBPL10 oxysterol binding protein-like 10
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSRC1 proline/serine-rich coiled-coil 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RPIA ribose 5-phosphate isomerase A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SULF1 sulfatase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THY1 Thy-1 cell surface antigen
TOP2A topoisomerase (DNA) II alpha 170kDa
VCAN versican