BRD-K03371390_7-fluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-40_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K03371390_7-fluoro-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-one KLK-40_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADIRF adipogenesis regulatory factor
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
BBX bobby sox homolog (Drosophila)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPB1 carboxypeptidase B1 (tissue)
CTTN cortactin
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
EDNRA endothelin receptor type A
ESR1 estrogen receptor 1
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA6 GATA binding protein 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGHMBP2 immunoglobulin mu binding protein 2
IL1R2 interleukin 1 receptor, type II
ITGA8 integrin, alpha 8
KRT19 keratin 19, type I
LRRC17 leucine rich repeat containing 17
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MB myoglobin
MDK midkine (neurite growth-promoting factor 2)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFN2 profilin 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLN phospholamban
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTN pleiotrophin
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRAD Ras-related associated with diabetes
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SIK1 salt-inducible kinase 1
SMAD7 SMAD family member 7
SUB1 SUB1 homolog (S. cerevisiae)
TM4SF1 transmembrane 4 L six family member 1
TMOD1 tropomodulin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
CCL20 chemokine (C-C motif) ligand 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
MAOA monoamine oxidase A
MTSS1 metastasis suppressor 1
NDRG1 N-myc downstream regulated 1
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN2 reticulon 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYPL1 synaptophysin-like 1
TBC1D4 TBC1 domain family, member 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLK2 tousled-like kinase 2
TMEM176B transmembrane protein 176B
TXNIP thioredoxin interacting protein
VCAN versican