BRD-K03063480_PF-477736_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K03063480_PF-477736_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ANXA2 annexin A2
AQP9 aquaporin 9
AREG amphiregulin
AURKA aurora kinase A
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
C5AR1 complement component 5a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CD302 CD302 molecule
CDC20 cell division cycle 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DHCR7 7-dehydrocholesterol reductase
DSP desmoplakin
ELOVL2 ELOVL fatty acid elongase 2
EMP3 epithelial membrane protein 3
EREG epiregulin
FAM46A family with sequence similarity 46, member A
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FDPS farnesyl diphosphate synthase
FGA fibrinogen alpha chain
FOS FBJ murine osteosarcoma viral oncogene homolog
GLRX glutaredoxin (thioltransferase)
GREB1 growth regulation by estrogen in breast cancer 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGL immunoglobulin lambda locus
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KIF20A kinesin family member 20A
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC59 leucine rich repeat containing 59
LYN LYN proto-oncogene, Src family tyrosine kinase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSLN mesothelin
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
ORM1 orosomucoid 1
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM4 PDZ and LIM domain 4
PID1 phosphotyrosine interaction domain containing 1
PLK1 polo-like kinase 1
PON3 paraoxonase 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RRAS related RAS viral (r-ras) oncogene homolog
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
TBX3 T-box 3
TESC tescalcin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VTN vitronectin
WBP5 WW domain binding protein 5
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AIM1 absent in melanoma 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AUTS2 autism susceptibility candidate 2
BHLHE41 basic helix-loop-helix family, member e41
C2CD5 C2 calcium-dependent domain containing 5
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFHD1 EF-hand domain family, member D1
ENO2 enolase 2 (gamma, neuronal)
FABP4 fatty acid binding protein 4, adipocyte
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCMR Fc fragment of IgM receptor
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSTM3 glutathione S-transferase mu 3 (brain)
HADH hydroxyacyl-CoA dehydrogenase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXC6 homeobox C6
KAZN kazrin, periplakin interacting protein
KRT19 keratin 19, type I
LAGE3 L antigen family, member 3
LOX lysyl oxidase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MME membrane metallo-endopeptidase
NEBL nebulette
NOTCH2 notch 2
NREP neuronal regeneration related protein
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G16 phospholipase A2, group XVI
PMP22 peripheral myelin protein 22
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
RCAN1 regulator of calcineurin 1
RGS1 regulator of G-protein signaling 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SSBP2 single-stranded DNA binding protein 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TRIL TLR4 interactor with leucine-rich repeats
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWF von Willebrand factor
ZMIZ1 zinc finger, MIZ-type containing 1