BRD-K03063480_PF-477736_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K03063480_PF-477736_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ANXA3 annexin A3
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BIRC3 baculoviral IAP repeat containing 3
CCL20 chemokine (C-C motif) ligand 20
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COG7 component of oligomeric golgi complex 7
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EGR1 early growth response 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERGIC3 ERGIC and golgi 3
FGG fibrinogen gamma chain
FOXA1 forkhead box A1
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HIST3H2A histone cluster 3, H2a
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IER5 immediate early response 5
IL6 interleukin 6
ITM2A integral membrane protein 2A
JUNB jun B proto-oncogene
KYNU kynureninase
LAMB2 laminin, beta 2 (laminin S)
LCN2 lipocalin 2
LTF lactotransferrin
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS1 Meis homeobox 1
MLPH melanophilin
MMP9 matrix metallopeptidase 9
MOAP1 modulator of apoptosis 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDGFRL platelet-derived growth factor receptor-like
PDZD2 PDZ domain containing 2
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLK2 polo-like kinase 2
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRDX2 peroxiredoxin 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RET ret proto-oncogene
RGS1 regulator of G-protein signaling 1
RPS21 ribosomal protein S21
S100P S100 calcium binding protein P
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
TFF1 trefoil factor 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8
TST thiosulfate sulfurtransferase (rhodanese)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
AKAP7 A kinase (PRKA) anchor protein 7
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL4C ADP-ribosylation factor-like 4C
CALB1 calbindin 1, 28kDa
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CIT citron rho-interacting serine/threonine kinase
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL14 chemokine (C-X-C motif) ligand 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUOX2 dual oxidase 2
DUSP7 dual specificity phosphatase 7
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FBP1 fructose-1,6-bisphosphatase 1
FHOD3 formin homology 2 domain containing 3
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GPM6A glycoprotein M6A
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
LRRC15 leucine rich repeat containing 15
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MDFIC MyoD family inhibitor domain containing
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
MICB MHC class I polypeptide-related sequence B
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTCL1 microtubule crosslinking factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PBX3 pre-B-cell leukemia homeobox 3
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RCAN2 regulator of calcineurin 2
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SDC4 syndecan 4
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SNX7 sorting nexin 7
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TMPO thymopoietin
TPD52 tumor protein D52
TYRP1 tyrosinase-related protein 1
VAV3 vav 3 guanine nucleotide exchange factor
VIM vimentin
WHSC1 Wolf-Hirschhorn syndrome candidate 1