BRD-K03063480_PF-477736_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K03063480_PF-477736_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CCND2 cyclin D2
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
ECM1 extracellular matrix protein 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GPX1 glutathione peroxidase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
INPP1 inositol polyphosphate-1-phosphatase
LIMCH1 LIM and calponin homology domains 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MIR22HG MIR22 host gene
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
RAP1GAP RAP1 GTPase activating protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RND3 Rho family GTPase 3
S100A14 S100 calcium binding protein A14
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
TM4SF1 transmembrane 4 L six family member 1
TRIM22 tripartite motif containing 22
VCAN versican
VIM vimentin

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
ATAD2 ATPase family, AAA domain containing 2
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CFH complement factor H
CHEK2 checkpoint kinase 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EMP2 epithelial membrane protein 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
LMNB1 lamin B1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PSIP1 PC4 and SFRS1 interacting protein 1
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TMPO thymopoietin
ZEB2 zinc finger E-box binding homeobox 2