BRD-K03063480_PF-477736_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K03063480_PF-477736_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
CARS cysteinyl-tRNA synthetase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CXORF40A chromosome X open reading frame 40A
CXORF40B chromosome X open reading frame 40B
DHRS2 dehydrogenase/reductase (SDR family) member 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FGL2 fibrinogen-like 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GAS1 growth arrest-specific 1
GLUL glutamate-ammonia ligase
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA2 heat shock 70kDa protein 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
KIF14 kinesin family member 14
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MIR22HG MIR22 host gene
MSL1 male-specific lethal 1 homolog (Drosophila)
MT1X metallothionein 1X
NKX2-2 NK2 homeobox 2
NPTX2 neuronal pentraxin II
NPY1R neuropeptide Y receptor Y1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTS neurotensin
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OLFM1 olfactomedin 1
PDLIM3 PDZ and LIM domain 3
PTN pleiotrophin
RABAC1 Rab acceptor 1 (prenylated)
RAP2A RAP2A, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RND3 Rho family GTPase 3
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNNT1 troponin T type 1 (skeletal, slow)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
USO1 USO1 vesicle transport factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AKR1C3 aldo-keto reductase family 1, member C3
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANXA4 annexin A4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BTBD3 BTB (POZ) domain containing 3
C10ORF10 chromosome 10 open reading frame 10
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD93 CD93 molecule
CHEK1 checkpoint kinase 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMBT1 deleted in malignant brain tumors 1
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DSP desmoplakin
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAMA4 laminin, alpha 4
LOC100505650 uncharacterized LOC100505650
LPL lipoprotein lipase
MAOA monoamine oxidase A
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MSN moesin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NREP neuronal regeneration related protein
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PCNA proliferating cell nuclear antigen
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAB25 RAB25, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC4 syndecan 4
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYMS thymidylate synthetase
ZNF395 zinc finger protein 395