BRD-K03063480_PF-477736_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

132 genes differentially expressed following the BRD-K03063480_PF-477736_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACYP2 acylphosphatase 2, muscle type
ADA adenosine deaminase
ADAM28 ADAM metallopeptidase domain 28
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BST2 bone marrow stromal cell antigen 2
CAMLG calcium modulating ligand
CD58 CD58 molecule
CPE carboxypeptidase E
CRP C-reactive protein, pentraxin-related
DCN decorin
EFNA1 ephrin-A1
FAM46A family with sequence similarity 46, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GPX3 glutathione peroxidase 3
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM2 interferon induced transmembrane protein 2
IFNGR1 interferon gamma receptor 1
ITM2A integral membrane protein 2A
KIZ kizuna centrosomal protein
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LITAF lipopolysaccharide-induced TNF factor
LYRM1 LYR motif containing 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MATN2 matrilin 2
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRNP prion protein
RABAC1 Rab acceptor 1 (prenylated)
RPL31 ribosomal protein L31
RPS21 ribosomal protein S21
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SIL1 SIL1 nucleotide exchange factor
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
TARP TCR gamma alternate reading frame protein
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TRIL TLR4 interactor with leucine-rich repeats
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATAD2 ATPase family, AAA domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CREB1 cAMP responsive element binding protein 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
EMP1 epithelial membrane protein 1
ETV5 ets variant 5
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MANSC1 MANSC domain containing 1
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NCAPG2 non-SMC condensin II complex, subunit G2
NET1 neuroepithelial cell transforming 1
NLRP2 NLR family, pyrin domain containing 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUP205 nucleoporin 205kDa
PGC progastricsin (pepsinogen C)
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTX3 pentraxin 3, long
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RGS4 regulator of G-protein signaling 4
RRM2 ribonucleotide reductase M2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIT2 slit homolog 2 (Drosophila)
SMAGP small cell adhesion glycoprotein
SVIL supervillin
TOP2A topoisomerase (DNA) II alpha 170kDa
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
ZWINT ZW10 interacting kinetochore protein