BRD-K03063480_PF-477736_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

167 genes differentially expressed following the BRD-K03063480_PF-477736_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CCL4 chemokine (C-C motif) ligand 4
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSTA cystatin A (stefin A)
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFNA1 ephrin-A1
EGR1 early growth response 1
FABP4 fatty acid binding protein 4, adipocyte
FBP1 fructose-1,6-bisphosphatase 1
FDXR ferredoxin reductase
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
JUNB jun B proto-oncogene
KIAA0753 KIAA0753
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT17 keratin 17, type I
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
NINJ1 ninjurin 1
NKG7 natural killer cell granule protein 7
NPY1R neuropeptide Y receptor Y1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH17 protocadherin 17
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PTPRC protein tyrosine phosphatase, receptor type, C
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLPI secretory leukocyte peptidase inhibitor
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRPS1 trichorhinophalangeal syndrome I
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMAT3 zinc finger, matrin-type 3
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADAM12 ADAM metallopeptidase domain 12
ADM adrenomedullin
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANXA5 annexin A5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BCAR3 breast cancer anti-estrogen resistance 3
BICC1 BicC family RNA binding protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLIC4 chloride intracellular channel 4
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EPHA3 EPH receptor A3
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HK1 hexokinase 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA10 homeobox A10
HOXB7 homeobox B7
HOXC6 homeobox C6
ITGA6 integrin, alpha 6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0125 KIAA0125
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAGED1 melanoma antigen family D1
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRN1 neuritin 1
PAX8 paired box 8
PFKP phosphofructokinase, platelet
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS23 protease, serine, 23
QPRT quinolinate phosphoribosyltransferase
RELN reelin
SEPT11 septin 11
SLC35F2 solute carrier family 35, member F2
SMS spermine synthase
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TALDO1 transaldolase 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TNC tenascin C
TUBB tubulin, beta class I
VCAN versican