BRD-K03063480_PF-477736_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K03063480_PF-477736_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AVPI1 arginine vasopressin-induced 1
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C1ORF116 chromosome 1 open reading frame 116
C8ORF4 chromosome 8 open reading frame 4
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP14 dual specificity phosphatase 14
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
EPN2 epsin 2
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
INPP1 inositol polyphosphate-1-phosphatase
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
KCTD5 potassium channel tetramerization domain containing 5
KIZ kizuna centrosomal protein
KLF4 Kruppel-like factor 4 (gut)
KLHDC10 kelch domain containing 10
KRT23 keratin 23, type I
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MEIS1 Meis homeobox 1
MOSPD1 motile sperm domain containing 1
MTSS1 metastasis suppressor 1
MUC2 mucin 2, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
NARS asparaginyl-tRNA synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS27L ribosomal protein S27-like
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SESN1 sestrin 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC38A1 solute carrier family 38, member 1
STK38L serine/threonine kinase 38 like
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNPO1 transportin 1
TP53I3 tumor protein p53 inducible protein 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
WDR19 WD repeat domain 19
XIST X inactive specific transcript (non-protein coding)
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AFP alpha-fetoprotein
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CYTL1 cytokine-like 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FEN1 flap structure-specific endonuclease 1
FGFR1 fibroblast growth factor receptor 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
FZD7 frizzled class receptor 7
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HK1 hexokinase 1
HMGB2 high mobility group box 2
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LMNB1 lamin B1
LMNB2 lamin B2
LPAR1 lysophosphatidic acid receptor 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MGP matrix Gla protein
MICB MHC class I polypeptide-related sequence B
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MSH2 mutS homolog 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NES nestin
NID1 nidogen 1
NMT2 N-myristoyltransferase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLBD1 phospholipase B domain containing 1
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
S100A7 S100 calcium binding protein A7
SAP30 Sin3A-associated protein, 30kDa
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIAM1 T-cell lymphoma invasion and metastasis 1
TK1 thymidine kinase 1, soluble
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WWTR1 WW domain containing transcription regulator 1
ZNF22 zinc finger protein 22