BRD-K02708799_GSK-1059615_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

147 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD10 ankyrin repeat domain 10
AQP9 aquaporin 9
ARG1 arginase 1
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CDK14 cyclin-dependent kinase 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP2 dual specificity phosphatase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FLG filaggrin
FOXO3 forkhead box O3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA3 GATA binding protein 3
GDF15 growth differentiation factor 15
HAL histidine ammonia-lyase
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF1 insulin-like growth factor 1 (somatomedin C)
IL1R2 interleukin 1 receptor, type II
KAT6B K(lysine) acetyltransferase 6B
KCTD12 potassium channel tetramerization domain containing 12
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
LOC100505650 uncharacterized LOC100505650
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MYLIP myosin regulatory light chain interacting protein
MYOF myoferlin
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
PNMAL1 paraneoplastic Ma antigen family-like 1
PPAP2B phosphatidic acid phosphatase type 2B
PRNP prion protein
PYCARD PYD and CARD domain containing
RPS4Y1 ribosomal protein S4, Y-linked 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC1A structural maintenance of chromosomes 1A
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIAM1 T-cell lymphoma invasion and metastasis 1
TNIP1 TNFAIP3 interacting protein 1
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TTC3 tetratricopeptide repeat domain 3
VAV3 vav 3 guanine nucleotide exchange factor
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALOX5 arachidonate 5-lipoxygenase
ANXA2P2 annexin A2 pseudogene 2
ANXA3 annexin A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARF6 ADP-ribosylation factor 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKLF chemokine-like factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCK deoxycytidine kinase
DDA1 DET1 and DDB1 associated 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLS glutaminase
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HN1 hematological and neurological expressed 1
HOMER3 homer scaffolding protein 3
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
KRT13 keratin 13, type I
KRT4 keratin 4, type II
KRT6B keratin 6B, type II
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LYZ lysozyme
MALL mal, T-cell differentiation protein-like
MGP matrix Gla protein
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NDN necdin, melanoma antigen (MAGE) family member
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
PIP prolactin-induced protein
PRKCB protein kinase C, beta
PRSS2 protease, serine, 2 (trypsin 2)
REG1A regenerating islet-derived 1 alpha
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SPATS2L spermatogenesis associated, serine-rich 2-like
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
TACC1 transforming, acidic coiled-coil containing protein 1
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
TUBB2A tubulin, beta 2A class IIa
WASF1 WAS protein family, member 1