BRD-K02708799_GSK-1059615_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

427 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM10 ADAM metallopeptidase domain 10
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AKAP9 A kinase (PRKA) anchor protein 9
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
APOD apolipoprotein D
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATXN1 ataxin 1
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CALCOCO1 calcium binding and coiled-coil domain 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CAPN2 calpain 2, (m/II) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A1 collagen, type I, alpha 1
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTH cystathionine gamma-lyase
CTSS cathepsin S
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOCK4 dedicator of cytokinesis 4
DSE dermatan sulfate epimerase
DSG2 desmoglein 2
EAPP E2F-associated phosphoprotein
EIF3D eukaryotic translation initiation factor 3, subunit D
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
FAM13A family with sequence similarity 13, member A
FBP1 fructose-1,6-bisphosphatase 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FN1 fibronectin 1
FNBP1L formin binding protein 1-like
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGB1 golgin B1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRN granulin
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGAV integrin, alpha V
JARID2 jumonji, AT rich interactive domain 2
KDM3A lysine (K)-specific demethylase 3A
KIAA0430 KIAA0430
KIAA1324 KIAA1324
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LCN2 lipocalin 2
LIMK2 LIM domain kinase 2
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED2 melanoma antigen family D2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
MGLL monoglyceride lipase
MLPH melanophilin
MT1F metallothionein 1F
MT1H metallothionein 1H
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NBR1 neighbor of BRCA1 gene 1
NCK2 NCK adaptor protein 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NMI N-myc (and STAT) interactor
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD6 programmed cell death 6
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PILRB paired immunoglobin-like type 2 receptor beta
PLAT plasminogen activator, tissue
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PSAT1 phosphoserine aminotransferase 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REEP5 receptor accessory protein 5
RGS10 regulator of G-protein signaling 10
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SH3YL1 SH3 and SYLF domain containing 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIDT2 SID1 transmembrane family, member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC35E2B solute carrier family 35, member E2B
SLC38A2 solute carrier family 38, member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STAG2 stromal antigen 2
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STXBP2 syntaxin binding protein 2
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYF2 SYF2 pre-mRNA-splicing factor
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TARBP1 TAR (HIV-1) RNA binding protein 1
TBL1X transducin (beta)-like 1X-linked
TGIF1 TGFB-induced factor homeobox 1
THY1 Thy-1 cell surface antigen
TJP2 tight junction protein 2
TMC5 transmembrane channel-like 5
TMEM63A transmembrane protein 63A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UBXN7 UBX domain protein 7
USP3 ubiquitin specific peptidase 3
VCAN versican
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZCCHC6 zinc finger, CCHC domain containing 6
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMYM2 zinc finger, MYM-type 2
ZNF217 zinc finger protein 217
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AKIRIN1 akirin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATAD2 ATPase family, AAA domain containing 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BIN1 bridging integrator 1
BMP2 bone morphogenetic protein 2
BST2 bone marrow stromal cell antigen 2
C1ORF116 chromosome 1 open reading frame 116
C1QBP complement component 1, q subcomponent binding protein
C1S complement component 1, s subcomponent
C20ORF24 chromosome 20 open reading frame 24
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CCND3 cyclin D3
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CKLF chemokine-like factor
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COMMD8 COMM domain containing 8
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNM1L dynamin 1-like
DPH2 DPH2 homolog (S. cerevisiae)
DPT dermatopontin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
ELOVL6 ELOVL fatty acid elongase 6
ENO1 enolase 1, (alpha)
F12 coagulation factor XII (Hageman factor)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GPR88 G protein-coupled receptor 88
GRB14 growth factor receptor-bound protein 14
GSTA1 glutathione S-transferase alpha 1
GZMK granzyme K (granzyme 3; tryptase II)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HBB hemoglobin, beta
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV3-19 immunoglobulin lambda variable 3-19
IL1RN interleukin 1 receptor antagonist
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KPNA3 karyopherin alpha 3 (importin alpha 4)
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LBR lamin B receptor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
LUM lumican
LYZ lysozyme
MALL mal, T-cell differentiation protein-like
MALT1 MALT1 paracaspase
MAOB monoamine oxidase B
MATN2 matrilin 2
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MRPL12 mitochondrial ribosomal protein L12
MSMO1 methylsterol monooxygenase 1
MTCH2 mitochondrial carrier 2
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
OLFM1 olfactomedin 1
PARP2 poly (ADP-ribose) polymerase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PFKP phosphofructokinase, platelet
PFN1 profilin 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PGRMC1 progesterone receptor membrane component 1
PHB prohibitin
PI3 peptidase inhibitor 3, skin-derived
PLAC8 placenta-specific 8
PLN phospholamban
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PSIP1 PC4 and SFRS1 interacting protein 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBKS ribokinase
RCAN2 regulator of calcineurin 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SFN stratifin
SFTPB surfactant protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORBS1 sorbin and SH3 domain containing 1
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SRM spermidine synthase
STRA13 stimulated by retinoic acid 13
SYNM synemin, intermediate filament protein
TCL1A T-cell leukemia/lymphoma 1A
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM147 transmembrane protein 147
TMEM97 transmembrane protein 97
TMX2 thioredoxin-related transmembrane protein 2
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPI1 triosephosphate isomerase 1
TPM1 tropomyosin 1 (alpha)
TPSAB1 tryptase alpha/beta 1
TRAPPC3 trafficking protein particle complex 3
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
WSB2 WD repeat and SOCS box containing 2
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZMIZ1 zinc finger, MIZ-type containing 1
ZWINT ZW10 interacting kinetochore protein