BRD-K02708799_GSK-1059615_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

367 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKMY2 ankyrin repeat and MYND domain containing 2
ANKRD36B ankyrin repeat domain 36B
ANO1 anoctamin 1, calcium activated chloride channel
ANXA1 annexin A1
ARG1 arginase 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATG12 autophagy related 12
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLDN3 claudin 3
COL5A2 collagen, type V, alpha 2
COPA coatomer protein complex, subunit alpha
CPM carboxypeptidase M
CREBL2 cAMP responsive element binding protein-like 2
CST1 cystatin SN
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CTSS cathepsin S
CTSV cathepsin V
CYTH1 cytohesin 1
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DST dystonin
DUSP1 dual specificity phosphatase 1
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF4B eukaryotic translation initiation factor 4B
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ERBB4 erb-b2 receptor tyrosine kinase 4
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GCC2 GRIP and coiled-coil domain containing 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GDF15 growth differentiation factor 15
GOLGA5 golgin A5
GPR137B G protein-coupled receptor 137B
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRN granulin
GSAP gamma-secretase activating protein
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-E major histocompatibility complex, class I, E
HOXC6 homeobox C6
IDE insulin-degrading enzyme
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIAA0430 KIAA0430
LCN2 lipocalin 2
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LOX lysyl oxidase
LRRC1 leucine rich repeat containing 1
LRRC17 leucine rich repeat containing 17
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLPH melanophilin
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PRKCSH protein kinase C substrate 80K-H
PSAT1 phosphoserine aminotransferase 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAD9A RAD9 homolog A (S. pombe)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS10 regulator of G-protein signaling 10
RHOBTB3 Rho-related BTB domain containing 3
RNF13 ring finger protein 13
RRAGD Ras-related GTP binding D
RSRP1 arginine/serine-rich protein 1
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
STC1 stanniocalcin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
SYT1 synaptotagmin I
TBL1X transducin (beta)-like 1X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TGIF1 TGFB-induced factor homeobox 1
TMEM63A transmembrane protein 63A
TNNT1 troponin T type 1 (skeletal, slow)
TOM1L1 target of myb1 (chicken)-like 1
TPP1 tripeptidyl peptidase I
TRAF5 TNF receptor-associated factor 5
TRAK2 trafficking protein, kinesin binding 2
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
VEGFA vascular endothelial growth factor A
VIM vimentin
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZCCHC6 zinc finger, CCHC domain containing 6
ZFAND1 zinc finger, AN1-type domain 1
ZNF451 zinc finger protein 451
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACTB actin, beta
ACTN1 actinin, alpha 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AK2 adenylate kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BST2 bone marrow stromal cell antigen 2
C1QBP complement component 1, q subcomponent binding protein
C20ORF24 chromosome 20 open reading frame 24
C3 complement component 3
CAPZB capping protein (actin filament) muscle Z-line, beta
CCND3 cyclin D3
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD320 CD320 molecule
CDC25A cell division cycle 25A
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CKB creatine kinase, brain
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN7 claudin 7
CLU clusterin
COX7B cytochrome c oxidase subunit VIIb
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTPS1 CTP synthase 1
CTSH cathepsin H
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
CYCS cytochrome c, somatic
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EFS embryonal Fyn-associated substrate
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL6 ELOVL fatty acid elongase 6
EMILIN1 elastin microfibril interfacer 1
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETF1 eukaryotic translation termination factor 1
FABP1 fatty acid binding protein 1, liver
FABP7 fatty acid binding protein 7, brain
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALE UDP-galactose-4-epimerase
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
GYG1 glycogenin 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
JCHAIN joining chain of multimeric IgA and IgM
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALT1 MALT1 paracaspase
MGST2 microsomal glutathione S-transferase 2
MPZL2 myelin protein zero-like 2
MRPL12 mitochondrial ribosomal protein L12
MRPS28 mitochondrial ribosomal protein S28
MRPS7 mitochondrial ribosomal protein S7
MXRA7 matrix-remodelling associated 7
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
P4HB prolyl 4-hydroxylase, beta polypeptide
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCP4 Purkinje cell protein 4
PDLIM2 PDZ and LIM domain 2 (mystique)
PFKP phosphofructokinase, platelet
PFN1 profilin 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGRMC1 progesterone receptor membrane component 1
PITX1 paired-like homeodomain 1
PLP1 proteolipid protein 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REEP1 receptor accessory protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RGS1 regulator of G-protein signaling 1
RPN2 ribophorin II
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SRM spermidine synthase
SRSF6 serine/arginine-rich splicing factor 6
STRA13 stimulated by retinoic acid 13
SYNGR2 synaptogyrin 2
TCF4 transcription factor 4
TFRC transferrin receptor
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM109 transmembrane protein 109
TMEM147 transmembrane protein 147
TMEM97 transmembrane protein 97
TPM1 tropomyosin 1 (alpha)
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR61 WD repeat domain 61