BRD-K02708799_GSK-1059615_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ADAM28 ADAM metallopeptidase domain 28
AGR2 anterior gradient 2
AKAP9 A kinase (PRKA) anchor protein 9
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPGM 2,3-bisphosphoglycerate mutase
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CCNG2 cyclin G2
CD24 CD24 molecule
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CPD carboxypeptidase D
CST1 cystatin SN
CST4 cystatin S
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSG2 desmoglein 2
DUSP4 dual specificity phosphatase 4
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GPR137B G protein-coupled receptor 137B
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HEBP2 heme binding protein 2
HLA-E major histocompatibility complex, class I, E
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IRS2 insulin receptor substrate 2
KAT6B K(lysine) acetyltransferase 6B
KDM5A lysine (K)-specific demethylase 5A
KLHDC2 kelch domain containing 2
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS8 lectin, galactoside-binding, soluble, 8
LOC100272216 uncharacterized LOC100272216
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LXN latexin
MAGED2 melanoma antigen family D2
MAN2A1 mannosidase, alpha, class 2A, member 1
MBNL2 muscleblind-like splicing regulator 2
MLPH melanophilin
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OBSL1 obscurin-like 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB2 SATB homeobox 2
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35E2B solute carrier family 35, member E2B
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TOM1L1 target of myb1 (chicken)-like 1
TRAF5 TNF receptor-associated factor 5
TRIM22 tripartite motif containing 22
TSC22D1 TSC22 domain family, member 1
TSPAN1 tetraspanin 1
UBXN4 UBX domain protein 4
VEZF1 vascular endothelial zinc finger 1
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK1 adenylate kinase 1
AK2 adenylate kinase 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
APOA1 apolipoprotein A-I
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CACYBP calcyclin binding protein
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
COL1A2 collagen, type I, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
ENO1 enolase 1, (alpha)
EXT1 exostosin glycosyltransferase 1
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGG fibrinogen gamma chain
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGKC immunoglobulin kappa constant
IL1RN interleukin 1 receptor antagonist
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMO4 LIM domain only 4
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MSMO1 methylsterol monooxygenase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NOP16 NOP16 nucleolar protein
NPY neuropeptide Y
NUDC nudC nuclear distribution protein
PBK PDZ binding kinase
PCP4 Purkinje cell protein 4
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PDZK1 PDZ domain containing 1
PGAM1 phosphoglycerate mutase 1 (brain)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLP1 proteolipid protein 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
REEP1 receptor accessory protein 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A7 S100 calcium binding protein A7
S100B S100 calcium binding protein B
SCG5 secretogranin V
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SRM spermidine synthase
STMN2 stathmin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAGLN2 transgelin 2
TBC1D31 TBC1 domain family, member 31
TCL1A T-cell leukemia/lymphoma 1A
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMEM147 transmembrane protein 147
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TNIK TRAF2 and NCK interacting kinase
TPM1 tropomyosin 1 (alpha)
TUBB4B tubulin, beta 4B class IVb
TUBG1 tubulin, gamma 1
UBE2S ubiquitin-conjugating enzyme E2S
UQCRC1 ubiquinol-cytochrome c reductase core protein I